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merck millipore,默克密理博,480418,NF279 - CAS 202983-32-2 - Calbiochem
产品名称：NF279 - CAS 202983-32-2 - Calbiochem
产品型号：480418
A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC₅₀/KB ~ 1 µM in smooth muscle).
merck millipore,默克密理博,480418,NF279 - CAS 202983-32-2 - Calbiochem
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经验配方 CAS号 C₄₉H₃₀N₆O₂₃S₆ · 6Na 202983-32-2 描述 概述 A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC50/KB ~ 1 µM in smooth muscle). Effectively discriminates between P2Y and P2X receptors with no effect on α1A adrenoceptors, adenosine A1 and A2B receptors, histamine H1, muscarinic M3 and neuronal nicotinic acetylcholine receptors. Displays a selectivity profile of P2X1 >P2X2 >P2X3 >P2X4 (IC50 = 19 nM, 770 nM, 1.62 µM and >300 µM, respectively) in Xenopus oocytes pre-incubated with ATP. In rat and human tissues, exhibits a potency profile of rat P2X1 > human P2X1 > > rat P2X2 > rat P2X3 ~ human P2X7 > > human P2X4. Not degraded by ecto-nucleotidases. 产品目录编号 480418 品牌系列 Calbiochem®
同义词 8,8ʹ-(Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino))bis-1,3,5-naphthalenetrisulfonic Acid, Na 参考 参考 Klapperstück, M., et al. 2000. Eur. J. Pharmacol. 387, 245.
Rettinger, J., et al. 2000. Neuropharmacol. 39, 2044.
Lambrecht, G., et al. 1999. Prog. Brain Res. 120,107.
Damer, S., et al. 1998. Eur. J. Pharmacol. 350, R5.产品信息 CAS号 202983-32-2 具有ATP竞争性 Y 形式 White solid Hill配方 C₄₉H₃₀N₆O₂₃S₆ · 6Na 化学配方 C₄₉H₃₀N₆O₂₃S₆ · 6Na Molar Mass 1401.1 可逆 Y 结构配方图像 生物信息 主靶 P2X receptor 主靶IC50 ~ 1 µM as antagonist of P2X receptor in smooth muscle; 19 nM, 770 nM, 1.62 µM and <300 µM, against P2X1, P2X2, P2X3, P2X4, respectively, in Xenopus oocytes pre-incubated with ATP 纯度 ≥99% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO or H₂O 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
防潮 Protect from moisture
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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