merck millipore,默克密理愽
  • merck millipore,默克密理博,05-1534,Anti-Gemin4 Antibody, clone 17D10

  • merck millipore,默克密理博,05-1534,Anti-Gemin4 Antibody, clone 17D10

    产品名称：Anti-Gemin4 Antibody, clone 17D10
    产品型号：05-1534
    Use Anti-Gemin4 Antibody, clone 17D10 (mouse monoclonal antibody) validated in WB, IP to detect Gemin4 also known as HCC-associated protein 1, component of gems 4, gem (nuclear organelle) associated p More>>

    merck millipore,默克密理博,05-1534,Anti-Gemin4 Antibody, clone 17D10

  • 产品介绍
  • merck millipore,默克密理博,05-1534,Anti-Gemin4 Antibody, clone 17D10

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-1534
    描述 Anti-Gemin4 Antibody, clone 17D10
    Alternate Names
    • gemin 4
    • HCC-associated protein 1
    • component of gems 4
    • gem (nuclear organelle) associated protein 4
    背景信息 Gemin4, also known as Component of Gems 4, is a component of the SMN complex. It is found in the cytoplasm, nucleoli, and to nuclear bodies called Gemini bodies (gems). As part of a complex this protein functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. Gemin4 directly interacts with the DEAD box protein, Gemin3, as well as other snRNP proteins, including SNRPB, SNRPD1, SNRPD2, SNRPD3 and SNRPE.
    The SMN complex is essential for the biogenesis of spliceosomal small nuclear ribonucleoproteins. Specifically, the SMN complex assembles 7 Sm proteins (Gemin2-8) into a core structure around a highly conserved sequence found in small nuclear RNAs. Reduced levels of SMN cause the motor neuron degenerative disease, spinal muscular atrophy.
    产品信息
    格式 Purified
    控制
    • HeLa cell lysate
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 Use Anti-Gemin4 Antibody, clone 17D10 (mouse monoclonal antibody) validated in WB, IP to detect Gemin4 also known as HCC-associated protein 1, component of gems 4, gem (nuclear organelle) associated protein 4.
    主要应用
    • Western Blotting
    应用说明 Immunoprecipitation:
    Reported by external laboratory using representative lot of this antibody.
    生物信息
    免疫原品种 Histidine-tagged recombinant protein corresponding to human Gemin4.
    表位 Unknown
    克隆 17D10
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes Gemin4.
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_056536
    Entrez基因汇总 The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq].
    基因符号
    • p97
    • GEMIN4
    • Gemin-4
    • HC56
    • HCAP1
    • HHRF-1
    纯化方法 Protein G purfied
    UniProt编号
    • P57678
    UniProt汇总 FUNCTION: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus.

    SUBUNIT STRUCTURE: Part of the core SMN complex that contains SMN1, SIP1/GEMIN2, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Interacts directly with GEMIN3 and with several snRNP SM core proteins, including SNRPB, SNRPD1, SNRPD2, SNRPD3 and SNRPE. Interacts with PPP4R2.

    SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus › nucleolus. Nucleus › gem. Note: Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs and in the nucleolus.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa cell lysate.

    Western Blot Analysis: 1 µg/ml of this antibody detected Gemin4 on 10 µg of HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-1534,Anti-Gemin4 Antibody, clone 17D10

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