• merck millipore,默克密理博,480403,NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem
  • merck millipore,默克密理博,480403,NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem

    产品名称:NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem
    产品型号:480403
    The NFAT Activation Inhibitor III, also referenced under CAS 3519-82-2, controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applicatio More>>

    merck millipore,默克密理博,480403,NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,480403,NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₀H₁₂O₂3519-82-2
    描述
    概述 A cell-permeable quinone compound that acts as a potent and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (Kd = 800 nM), disrupts its interaction with NFAT and completely blocks its dephosphorylation, nuclear import of NFAT (~40 µM in C1.7W2 T cells), and induction of cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling.
    产品目录编号 480403
    品牌系列 Calbiochem®
    同义词 Inhibitor of NFAT-Calcineurin Association-6, INCA-6
    参考
    参考 Roehrl, M.H.A., et al. 2004. Biochemistry 43, 16067.
    Roehrl, M.H.A., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7554.
    产品信息
    CAS号 3519-82-2
    具有ATP竞争性 N
    形式 Yellow solid
    Hill配方 C₂₀H₁₂O₂
    化学配方 C₂₀H₁₂O₂
    Molar Mass 284.3
    可逆 N
    结构配方图像
    生物信息
    主靶 Calcineurin-NFAT
    主靶IC50 Kd = 800 nM for calcineurin-NFAT
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Carcinogenic / Teratogenic
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

    merck millipore,默克密理博,480403,NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem

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