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merck millipore,默克密理博,480403,NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem
产品名称:NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem
产品型号:480403
The NFAT Activation Inhibitor III, also referenced under CAS 3519-82-2, controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applicatio More>>
merck millipore,默克密理博,480403,NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₀H₁₂O₂ 3519-82-2 描述 概述 A cell-permeable quinone compound that acts as a potent and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (Kd = 800 nM), disrupts its interaction with NFAT and completely blocks its dephosphorylation, nuclear import of NFAT (~40 µM in C1.7W2 T cells), and induction of cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling. 产品目录编号 480403 品牌系列 Calbiochem®
同义词 Inhibitor of NFAT-Calcineurin Association-6, INCA-6 参考 参考 Roehrl, M.H.A., et al. 2004. Biochemistry 43, 16067.
Roehrl, M.H.A., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7554.产品信息 CAS号 3519-82-2 具有ATP竞争性 N 形式 Yellow solid Hill配方 C₂₀H₁₂O₂ 化学配方 C₂₀H₁₂O₂ Molar Mass 284.3 可逆 N 结构配方图像 生物信息 主靶 Calcineurin-NFAT 主靶IC50 Kd = 800 nM for calcineurin-NFAT 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Carcinogenic / Teratogenic
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
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