merck millipore,默克密理愽
  • merck millipore,默克密理博,476496,Protein Lysine Methyltransferase Inhibitor, UNC0321 - Calbiochem

  • merck millipore,默克密理博,476496,Protein Lysine Methyltransferase Inhibitor, UNC0321 - Calbiochem

    产品名称：Protein Lysine Methyltransferase Inhibitor, UNC0321 - Calbiochem
    产品型号：476496


    merck millipore,默克密理博,476496,Protein Lysine Methyltransferase Inhibitor, UNC0321 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,476496,Protein Lysine Methyltransferase Inhibitor, UNC0321 - Calbiochem

    重要规格表

    经验配方
    C₂₇H₄₅N₇O₃
    描述
    概述 A cell-permeable, quinazoline analog that potently and selectively inhibits PKMT G9a (IC50 = 6 nM and 9 nM in two biochemical assays for CLOT and ECSD, respectively, and Ki = 63 pM, which is approximately 250-fold more potent than a closely-related analog, BIX01294 (Cat. No. 382190)). It inhibits GLP with reduced potency (15 nM) and is found to be inactive (IC50 > 40 µM) toward other protein lysine and arginine methyltransferases, such as SET7/9 (aH3K4 PKMT), SET8/PreSET7 (aH4K20 PKMT), and PRMT3, as well as JMJD2E (> 1000-fold selectivity) in ECSD enzymatic assays. It also inhibits H3K9me2 accumulation (IC50 = 11,000 nM) in MDA-MB-231 cells, in comparison to BIX01294 (IC50 = 500 nM).

    Please note that the molecular weight for this compound is batch-specific due to variable water content.
    产品目录编号 476496
    品牌系列 Calbiochem®
    同义词 7-(2-(2-(Dimethylamino)ethoxy)ethoxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
    参考
    参考 Liu, F., et al. 2010. J. Med. Chem. 53, 5844.
    产品信息
    形式 Light tan solid
    Hill配方 C₂₇H₄₅N₇O₃
    化学配方 C₂₇H₄₅N₇O₃
    结构配方图像
    生物信息
    纯度 >98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,476496,Protein Lysine Methyltransferase Inhibitor, UNC0321 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,217386,Carboxy-PTIO, Sodium Salt - Calbiochem


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