merck millipore,默克密理愽
  • merck millipore,默克密理博,23-023M,SCF-Skp2 Protein Complex, Active, 250 µg

  • merck millipore,默克密理博,23-023M,SCF-Skp2 Protein Complex, Active, 250 µg

    产品名称：SCF-Skp2 Protein Complex, Active, 250 µg
    产品型号：23-023M
    Active complex of five (5) full length, recombinant human enzymes: Skp1, Skp2, Cul1, Rbx1 & Cks1. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

    merck millipore,默克密理博,23-023M,SCF-Skp2 Protein Complex, Active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,23-023M,SCF-Skp2 Protein Complex, Active, 250 µg

    重要规格表

    主要应用 品种 级联部件
    EAHumanE3
    描述
    产品目录编号 23-023M
    品牌系列 Upstate
    商名
    • Upstate
    描述 SCF-Skp2 Protein Complex, Active, 250 µg
    长描述 Complex of N-terminal 6His-tagged, recombinant human Skp2 full length, N-terminal GST-tagged, recombinant human Skp1 full length, N-terminal 6His-tagged, recombinant human Cul1 full length and untagged recombinant human Rbx1 full length, co-expressed by baculovirus in Sf21 insect cells. Purified using glutathione sepharose and complexed in vitro with C-terminal 6His-tagged, recombinant human Cks1 full length expressed in E.coli
    Alternate Names
    • SCF<sup>Skp2</sup>
    • Skp2/Cks1 complex
    背景信息 The SCF (Skp1-Cul1-F-box protein) complexes represent the largest family of ubiquitin-protein ligases and mediate the ubiquitination of a broad spectrum of regulatory and signalling proteins in diverse cellular pathways. The SCF consists of three invariant components, Skp1, Cul1 and Rbx1 and an interchangeable subunit, an F-box protein which is responsible for recruiting specific substrates to be ubiquitinated by the SCF. SCFSkp2 mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated p27 and is involved in regulation of G1/S transition. Complex formation of SCFSkp2 with Cks1 is required for the degradation of p27. An increased level of Skp2 and reduced level of p27 is linked to poor prognosis in a number of cancers
    应用
    应用 Active complex of five (5) full length, recombinant human enzymes: Skp1, Skp2, Cul1, Rbx1 & Cks1. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
    主要应用
    • Enzyme Assay
    生物信息
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    级联部件 E3
    Entrez基因编号
    • NM_001826 (Cks1) (GenBank Number)
    • NM_005983 (Skp2) (GenBank Number)
    • NM_170679 (Skp1) (GenBank Number)
    • NM_003592 (Cul1) (GenBank Number)
    • NM_014248 (Rbx1) (GenBank Number)
    纯化方法 Purified using immobilized metal affinity chromatography.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 250 µg

    merck millipore,默克密理博,23-023M,SCF-Skp2 Protein Complex, Active, 250 µg

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