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merck millipore,默克密理博,475986,mTOR Kinase Inhibitor II, WYE-354 - CAS 1062169-56-5 - Calbiochem
产品名称：mTOR Kinase Inhibitor II, WYE-354 - CAS 1062169-56-5 - Calbiochem
产品型号：475986
The mTOR Kinase Inhibitor II, WYE-354, also referenced under CAS 1062169-56-5, controls the biological activity of mTOR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephospho More>>
merck millipore,默克密理博,475986,mTOR Kinase Inhibitor II, WYE-354 - CAS 1062169-56-5 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₄H₂₉N₇O₅ 1062169-56-5 描述 概述 A cell-permeable pyrazolopyrimidine compound that acts as a potent and ATP-competitive mTOR inhibitor (IC50 = 5 nM with S6K as the substrate and 100 µM ATP) with much reduced activity against PI 3-Kα or PI 3-Kγ (IC50 = 1.89 and 7.37 µM, respectively) and little or no activity toward 24 other kinases (IC50 >50 µM). WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and Akt as the respective substrate (IC50 <200 nM; [ATP] = 100 µM) and effectively blocks cellular phosphorylation of S6K on T389 and Akt on S473 both in cultures and in a murine xenograft model, resulting in a significant suppression of PC3MM2-derived tumor growth (by 86% on day 7; 50 mg/kg, i.p twice per day) in vivo. 产品目录编号 475986 品牌系列 Calbiochem®
同义词 Methyl-4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate, mTOR Inhibitor II 参考 参考 Yu, K., et al. 2009. Cancer Res. 69, 6232.
Zask, A., et al. 2009. J. Med. Chem. 52, 5013.产品信息 CAS号 1062169-56-5 形式 White solid Hill配方 C₂₄H₂₉N₇O₅ 化学配方 C₂₄H₂₉N₇O₅ Molar Mass 495.5 结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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