merck millipore,默克密理愽
  • merck millipore,默克密理博,444295,MT1-MMP Inhibitor, NSC405020 - Calbiochem

  • merck millipore,默克密理博,444295,MT1-MMP Inhibitor, NSC405020 - Calbiochem

    产品名称：MT1-MMP Inhibitor, NSC405020 - Calbiochem
    产品型号：444295
    The MT1-MMP Inhibitor, NSC405020 controls the biological activity of MT1-MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

    merck millipore,默克密理博,444295,MT1-MMP Inhibitor, NSC405020 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,444295,MT1-MMP Inhibitor, NSC405020 - Calbiochem

    重要规格表

    经验配方
    C₁₂H₁₅Cl₂NO
    描述
    概述 A cell-permeable pentanylbenzamide compound that acts as an allosteric, reversible, and selective inhibitor of the collgenolytic activity of MT1-MMP. Does not affect the catalytic activity of cellular MT-1-MMP thus allows it to retain its ability to activate MMP-2. Selectively targets the hemopexin (PEX) domain of MT1-MMP, thereby repressing its pro-tumorigenic activity. Its binding to the PEX domain is dependent on Met-328, Arg-330, Asp-376, Met-422, and Ser-470 in the druggable pocket of the enzyme. Shown to block 184B5-MT cell migration on collagen-1 and repress MCF7-β3/MT tumor growth in xenografted mice (0.5 mg/kg, intratumoral).
    产品目录编号 444295
    品牌系列 Calbiochem®
    同义词 3,4-Dichloro-N-(pentan-2-yl)benzamide, 3,4-Dichloro-N-(1-methylbutyl)benzamide
    参考
    参考 Remacle, A.G., et al. 2012. Cancer Res. 72, 2339.
    产品信息
    形式 Off-white solid
    Hill配方 C₁₂H₁₅Cl₂NO
    化学配方 C₁₂H₁₅Cl₂NO
    Molar Mass 260.2
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,444295,MT1-MMP Inhibitor, NSC405020 - Calbiochem

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