merck millipore,默克密理愽
  • merck millipore,默克密理博,05-878,Anti-Protein C Antibody, clone GMA-093

  • merck millipore,默克密理博,05-878,Anti-Protein C Antibody, clone GMA-093

    产品名称：Anti-Protein C Antibody, clone GMA-093
    产品型号：05-878
    Anti-Protein C Antibody, clone GMA-093 detects level of Protein C & has been published & validated for use in ELISA & WB.

    merck millipore,默克密理博,05-878,Anti-Protein C Antibody, clone GMA-093

  • 产品介绍
  • merck millipore,默克密理博,05-878,Anti-Protein C Antibody, clone GMA-093

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, ELISAMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-878
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Protein C Antibody, clone GMA-093
    产品信息
    格式 Purified
    应用
    应用 Anti-Protein C Antibody, clone GMA-093 detects level of Protein C & has been published & validated for use in ELISA & WB.
    主要应用
    • Western Blotting
    • ELISA
    生物信息
    免疫原品种 Purified human Protein C
    克隆 GMA-093
    宿主 Mouse
    特异性 Protein C
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000312
    基因符号
    • PROC1
    • PROC
    纯化方法 DEAE purified
    UniProt编号
    • P04070
    UniProt汇总 FUNCTION: SwissProt: P04070 # Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.
    SIZE: 461 amino acids; 52071 Da
    SUBUNIT: Synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain; this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin.
    TISSUE SPECIFICITY: Plasma; synthesized in the liver.
    PTM: The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium. & Partial (70%) N-glycosylation of Asn-371 with an atypical N- X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not glycosylated at Asn- 371, is beta.
    DISEASE: "SwissProt: P04070 # Defects in PROC are the cause of protein C deficiency (PROC deficiency) [MIM:176860]. PROC deficiency is an important risk factor for hereditary thrombophilia [MIM:188050], a multifactorial trait characterized by recurrent thrombosis and abnormal platelet aggregation in response to various agents. A severe recessive form of PROC deficiency results in neonatal death through massive neonatal venous thrombosis. Often associated with ecchymotic skin lesions which can turn necrotic called purpura fulminans, this disorder is very rare and has an incidence of about 1:500,000 live births. Most cases of PROC deficiency have had a quantitative defect in the protein C molecule. PROC deficiency with a mutation that causes diminished synthesis of protein has been referred to as type I and that with synthesis of a dysfunctional molecule as type II."SIMILARITY:SwissProt: P04070 ## Belongs to the peptidase S1 family. & Contains 2 EGF-like domains. & Contains 1 Gla (gamma-carboxy-glutamate) domain. & Contains 1 peptidase S1 domain.
    MISCELLANEOUS: Calcium also binds, with stronger affinity to another site, beyond the GLA domain. This GLA-independent binding site is necessary for the recognition of the thrombin- thrombomodulin complex.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on human Protein C
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 stable 2 years at -20°C from date of shipment
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-878,Anti-Protein C Antibody, clone GMA-093

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