merck millipore,默克密理博,04-324,Anti-AMPKβ1 Antibody, rabbit monoclonal

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merck millipore,默克密理博,04-324,Anti-AMPKβ1 Antibody, rabbit monoclonal
产品名称：Anti-AMPKβ1 Antibody, rabbit monoclonal
产品型号：04-324
Anti-AMPKβ1 Antibody, Rabbit detects level of AMPKβ1 & has been published & validated for use in FC, IH(P), IP & WB.

merck millipore,默克密理博,04-324,Anti-AMPKβ1 Antibody, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-324,Anti-AMPKβ1 Antibody, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	WB, FC	Rb	Purified	Monoclonal Antibody

描述
产品目录编号	04-324
品牌系列	Upstate
商名	Upstate
描述	Anti-AMPKβ1 Antibody, rabbit monoclonal
Alternate Names	PRKAB1, AMPK, AMPKb1, AMPK beta 1, protein kinase, AMP-activated, beta 1 non-catalytic subunit PRKAB1 AMPK AMPKb1 AMPK beta 1 protein kinase AMP-activated

产品信息
格式	Purified
演示	In 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.

应用
应用	Anti-AMPKβ1 Antibody, Rabbit detects level of AMPKβ1 & has been published & validated for use in FC, IH(P), IP & WB.
主要应用	Western Blotting Flow Cytometry

生物信息
免疫原品种	KLH-conjugated synthetic peptide corresponding to human AMPKβ1.
宿主	Rabbit
特异性	Recognizes AMPKβ1.
同种型	IgG
品种反应性	RatHumanMouse
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_006253.4
Entrez基因汇总	The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
基因符号	MGC17785 PRKAB1 AMPKb AMPK HAMPKb
UniProt编号	Q9Y478
UniProt汇总	FUNCTION: SwissProt: Q9Y478 # AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone- sensitive lipase. This is a regulatory subunit, may be a positive regulator of AMPK activity. It may also serve as an adaptor molecule for the catalytic alpha-subunit. SIZE: 270 amino acids; 30382 Da SUBUNIT: Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic regulatory subunits. Interacts with FNIP1. PTM: Phosphorylated (By similarity). SIMILARITY: SwissProt: Q9Y478 ## Belongs to the 5'-AMP-activated protein kinase beta subunit family.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

储存和货运信息

存储条件

2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.