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  • merck millipore,默克密理博,AB5666P,Anti-Neurite Outgrowth Inhibitor A/B/C Antibody

  • merck millipore,默克密理博,AB5666P,Anti-Neurite Outgrowth Inhibitor A/B/C Antibody

    产品名称：Anti-Neurite Outgrowth Inhibitor A/B/C Antibody
    产品型号：AB5666P
    Anti-Neurite Outgrowth Inhibitor A/B/C Antibody is an antibody against Neurite Outgrowth Inhibitor A/B/C for use in ELISA & WB.

    merck millipore,默克密理博,AB5666P,Anti-Neurite Outgrowth Inhibitor A/B/C Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5666P,Anti-Neurite Outgrowth Inhibitor A/B/C Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWB, ELISARbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5666P
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Neurite Outgrowth Inhibitor A/B/C Antibody
    Alternate Names
    • Nogo-A/B/C
    产品信息
    格式 Affinity Purified
    演示 Liquid in PBS containing 0.1% BSA and 0.05% sodium azide.
    应用
    应用 Anti-Neurite Outgrowth Inhibitor A/B/C Antibody is an antibody against Neurite Outgrowth Inhibitor A/B/C for use in ELISA & WB.
    主要应用
    • Western Blotting
    • ELISA
    应用说明 Western blot: 1-10 μg/mL using ECL. The calculated molecular weight of Nogo-A is approximately 135 kDa. However a molecular weight of approximately 180 kDa has been reported for full length Nogo-A (Chen et al. 2000; GrandPre et al. 2000; Goldberg & Barres 2000; Prinijha et al. 2000; Tessier-Lavigne & Goodman 2000; Nagase et al. 1998).



    ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 A 13 amino acid peptide between the putative 2nd-3rd transmembrane domain of human Nogo-A (Chen et al. 2000; GrandPre et al. 2000; Goldberg & Barres 2000; Prinijha et al. 2000; Tessier-Lavigne & Goodman 2000; Nagase et al. 1998).
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes human Neurite Outgrowth Inhibitor Protein A/B/C (Nogo-A/B/C). The immunogen peptide is within the 25 amino acid region identified for the inhibition of neurite outgrowth (Chen et al. 2000; GrandPre et al. 2000; Goldberg & Barres 2000; Prinijha et al. 2000; Tessier-Lavigne & Goodman 2000; Nagase et al. 1998).The immunogen shows no significant sequence homology with other known proteins.

    SPECIES REACTIVITIES: The immunogen peptide is 92% conserved in rat Nogo or rat foocen-m1.2 protein (Chen et al. 2000; GrandPre et al. 2000; Goldberg & Barres 2000; Prinijha et al. 2000; Tessier-Lavigne & Goodman 2000; Nagase et al. 1998). Reactivity with other species has not been confirmed.
    品种反应性 RatHumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_207521.1
    • NM_007008.2
    • NM_020532.4
    • NM_153828.2
    • NM_207520.1
    Entrez基因汇总 This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified.
    基因符号
    • Nogo-B
    • RTN4
    • RTN4-B1
    • Nbla10545
    • RTN-X
    • reticulon-4A
    • Nogo-C
    • NSP
    • RTN-x
    • ASY
    • foocen
    • NSP-CL
    • NOGOC
    • RTN4-A
    • Reticulon-4
    • Nbla00271
    • KIAA0886
    • NOGOA
    • Reticulon-5
    • Foocen
    • NI220/250
    • RTN4-C
    • RTN4-B2
    • SP1507
    • NOGO-A
    • NOGO
    • NOGOB
    UniProt编号
    • Q9NQC3
    UniProt汇总 FUNCTION: SwissProt: Q9NQC3 # Potent neurite growth inhibitor in vitro and plays a role both in the restriction of axonal regeneration after injury and in structural plasticity in the CNS. Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.
    SIZE: 1192 amino acids; 129931 Da
    SUBUNIT: Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Isoform 2 binds to NGBR and RTN3. Isoform 2 and isoform 3 interact with BACE1 and BACE2.
    SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains.
    TISSUE SPECIFICITY: Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis- specific.
    DOMAIN: SwissProt: Q9NQC3 Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane domains, known as Nogo- 66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity).
    SIMILARITY: Contains 1 reticulon domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB5666P,Anti-Neurite Outgrowth Inhibitor A/B/C Antibody

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