merck millipore,默克密理愽
  • merck millipore,默克密理博,420210,Jervine - CAS 469-59-0 - Calbiochem

  • merck millipore,默克密理博,420210,Jervine - CAS 469-59-0 - Calbiochem

    产品名称：Jervine - CAS 469-59-0 - Calbiochem
    产品型号：420210
    A cell-permeable steroidal alkaloid similar to cyclopamine that displays teratogenic effects and induces cyclopia by blocking Sonic Hedgehog signaling.

    merck millipore,默克密理博,420210,Jervine - CAS 469-59-0 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,420210,Jervine - CAS 469-59-0 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₇H₃₉NO₃469-59-0
    描述
    概述 A cell-permeable steroidal alkaloid similar to cyclopamine (Cat. No. 239803) that displays teratogenic effects and induces cyclopia by blocking shh (Sonic Hedgehog) signaling (IC50 = ~ 500-700 nM in s12 cells). Tomatidine (Cat. No. 614350) serves as a suitable negative control.
    产品目录编号 420210
    品牌系列 Calbiochem®
    同义词 (3β, 23β)-17,23-Epoxy-3-hydroxyveratraman-11-one, 11-Ketocyclopamine, Shh Signaling Antagonist III
    参考
    参考 Williams, J.A., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 4616.
    Cooper, M. K., et al. 2003. Nat. Genet. 33, 508.
    Mistretta, C.M., 2003. Dev. Biol. 254, 1.
    ten Berge, D., et al. 2001. Development 128, 2929.
    Cooper, M.K., et al. 1998. Science 280, 1603.
    产品信息
    CAS号 469-59-0
    具有ATP竞争性 N
    形式 Off-white solid
    Hill配方 C₂₇H₃₉NO₃
    化学配方 C₂₇H₃₉NO₃
    Molar Mass 425.6
    可逆 N
    结构配方图像
    生物信息
    主靶 Induces cyclopia by blocking shh (Sonic Hedgehog) signaling
    主靶IC50 ~ 500-700 nM blocking shh (Sonic Hedgehog) signaling in s12 cells
    纯度 ≥98% by HPLC; single spot by TLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or EtOH
    GHS安全信息
    RTECS WG9700000
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Toxic
    有害材料注意事项： Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
    储存 -20°C
    无需冷冻 No
    特殊指南 Following reconstitution in fresh DMSO, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,420210,Jervine - CAS 469-59-0 - Calbiochem

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