- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
描述 产品目录编号 14-569M 品牌系列 Upstate
商名 - Upstate
描述 ErbB4 Protein, active, 250 µg 概述 N-Terminal His6-tagged, recombinant, human ErbB4 amino acids 706-991 Alternate Names - Tyrosine kinase-type cell surface receptor HER4
- p180erbB4
- Receptor Tyrosine-protein kinase erbB-4
应用 应用 Active, N-Terminal His6-tagged, recombinant, human ErbB4 amino acids 706-991, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 expressed by baculovirus in Sf21 insect cells 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_001982.2
- NM_001005915.1
Entrez基因汇总 This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. 基因符号 - HER4
- ERBB4
蛋白靶 ErbB4 纯化方法 Ni2+/NTA-agarose 靶子系列 TK UniProt编号 - Q15303
UniProt汇总 FUNCTION: SwissProt: P21860 # Binds and is activated by neuregulins and NTAK.
SIZE: 1342 amino acids; 148098 Da
SUBUNIT: Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5 and PA2G4.
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
TISSUE SPECIFICITY: Epithelial tissues and brain.
DOMAIN: SwissProt: P21860 The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.
PTM: Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (By similarity).
DISEASE: SwissProt: P21860 # Overexpressed in a subset of human mammary tumors. & Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1) 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70C 包装信息 数量 250 µg 包装 Also available in 10 μg size (cat#14-569) and in bulk (cat# 14-569-K).
上一件merck millipore产品：merck millipore,默克密理博,14-696,MAP Kinase 2/Erk 2 (K52R), inactive, 100 µg
下一件merck millipore产品：merck millipore,默克密理博,420210,Jervine - CAS 469-59-0 - Calbiochem
相关产品
merck millipore,默克密理博,ELI-008-M,IL-6 ELISPOT Antibody Pair, Mouse
merck millipore,默克密理博,108337,葡萄糖
merck millipore,默克密理博,ABD136,Anti-LGI1 Antibody
merck millipore,默克密理博,SF-2472,FOXP2; Human, Cyanine 5 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,14-696,MAP Kinase 2/Erk 2 (K52R), inactive, 100 µg
merck millipore,默克密理博,420210,Jervine - CAS 469-59-0 - Calbiochem
merck millipore,默克密理博,14-132,p13suc1 Protein, agarose conjugate, Yeast, 2.5 mg
