merck millipore,默克密理愽
  • merck millipore,默克密理博,14-696,MAP Kinase 2/Erk 2 (K52R), inactive, 100 µg

  • merck millipore,默克密理博,14-696,MAP Kinase 2/Erk 2 (K52R), inactive, 100 µg

    产品名称：MAP Kinase 2/Erk 2 (K52R), inactive, 100 µg
    产品型号：14-696
    Inactive, N-terminal 6His-tagged recombinant full-length mouse MAP Kinase 2/Erk2 containing a K52R mutation, for use in Kinase Assays.

    merck millipore,默克密理博,14-696,MAP Kinase 2/Erk 2 (K52R), inactive, 100 µg

  • 产品介绍
  • merck millipore,默克密理博,14-696,MAP Kinase 2/Erk 2 (K52R), inactive, 100 µg

    描述
    产品目录编号 14-696
    品牌系列 Upstate
    商名
    • Upstate
    描述 MAP Kinase 2/Erk 2 (K52R), inactive, 100 µg
    概述 N-terminal 6His-tagged recombinant full-length mouse MAP Kinase 2/Erk2 containing a K52R mutation
    应用
    应用 Inactive, N-terminal 6His-tagged recombinant full-length mouse MAP Kinase 2/Erk2 containing a K52R mutation, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 expressed in E. coli
    品种 E. coli
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_011949.3
    Entrez基因汇总 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
    基因符号
    • ERK2
    • MAPK1
    • p40
    • PRKM2
    • MAPK2
    • PRKM1
    • p42-MAPK
    • p38
    • ERK
    • ERK-2
    • ERT1
    • P54MAPK
    • P41MAPK
    蛋白靶 MAPK2
    纯化方法 Ni2+/NTA-agarose
    靶子系列 CMGC
    UniProt编号
    • P63085
    UniProt汇总 FUNCTION: SwissProt: P63085 #Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The the MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis.
    COFACTOR: Magnesium (By similarity).
    DOMAIN: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
    SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 MAP Kinase 2/Erk2 (K52R), inactive was phosphorylated by MEK1 (Catalog # 14-429), and the results confirmed by Western blotting using Anti-phospho-MAP Kinase 1/2 (Erk1/2) (Catalog #07-467). The absence of kinase activity of the phosphorylated MAP Kinase 2/Erk2 (K52R) was tested using MBP (Catalog # 13-110) as a substrate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at -20°C from date of shipment
    包装信息
    数量 100 µg

    merck millipore,默克密理博,14-696,MAP Kinase 2/Erk 2 (K52R), inactive, 100 µg

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