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merck millipore,默克密理博,420203,JMJD Histone Demethylase Inhibitor IV, Methylstat - CAS 1310877-95-2 - Calbiochem
产品名称：JMJD Histone Demethylase Inhibitor IV, Methylstat - CAS 1310877-95-2 - Calbiochem
产品型号：420203
The JMJD Histone Demethylase Inhibitor IV, Methylstat controls the biological activity of JMJD Histone Demethylase. This small molecule/inhibitor is primarily used for Cell Structure applications.
merck millipore,默克密理博,420203,JMJD Histone Demethylase Inhibitor IV, Methylstat - CAS 1310877-95-2 - Calbiochem
- 产品介绍
- merck millipore,默克密理博,420203,JMJD Histone Demethylase Inhibitor IV, Methylstat - CAS 1310877-95-2 - Calbiochem
重要规格表
经验配方 CAS号 C₂₈H₃₁N₃O6 1310877-95-2 描述 概述 A methyl ester prodrug of in vitro active N-hydroxybutenoic acid compound (Cat. No. 420202) that is shown to preferentially induce hypermethylation of histone proteins (EC50 for H3K4me3 and H3K9me3 = 10.3 and 8.6 µM in KYSE150 cells, and 6.7 and 6.3 µM in MCF7 cells, respectively), and arrests cell growth. Acts as a selective inhibitor of Jumonji domain-containing histone demethylases (JHDMs) over prolyl hydroxylases (PHDs), and prevents myogenesis through inhibition of H3K27 demethylase UTX in C2C12 cells at 2 µM. 产品目录编号 420203 品牌系列 Calbiochem®
同义词 (E)-Methyl-4-(hydroxy(4-((4-(((naphthalen-1-ylcarbamoyl)oxy)methyl)benzyl)amino)butyl)amino)-4-oxobut-2-enoate, Histone Lysine Demethylase Inhibitor VII, JHDM Inhibitor IV 参考 参考 Luo, X., et al. 2011. J. Am. Chem. Soc. 133, 9451. 产品信息 CAS号 1310877-95-2 形式 Off-white powder Hill配方 C₂₈H₃₁N₃O6 化学配方 C₂₈H₃₁N₃O6 Molar Mass 505.6 结构配方图像 生物信息 纯度 ≥96% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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