merck millipore,默克密理愽
  • merck millipore,默克密理博,407247,IGF-1R Inhibitor, PPP - CAS 477-47-4 - Calbiochem

  • merck millipore,默克密理博,407247,IGF-1R Inhibitor, PPP - CAS 477-47-4 - Calbiochem

    产品名称：IGF-1R Inhibitor, PPP - CAS 477-47-4 - Calbiochem
    产品型号：407247
    The IGF-1R Inhibitor, PPP, also referenced under CAS 477-47-4, controls the biological activity of IGF-1R. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation appli More>>

    merck millipore,默克密理博,407247,IGF-1R Inhibitor, PPP - CAS 477-47-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,407247,IGF-1R Inhibitor, PPP - CAS 477-47-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₂H₂₂O₈477-47-4
    描述
    概述 A cell-permeable cis-cyclolignan compound that acts as a substrate competitive, reversible, potent, and specific inhibitor of IGF-1R both in vitro (IC50 = 1 nM in cell-free kinase assay; ≤ 60 nM for cell viability and receptor autophosphorylation in melanoma cell lines) and in vivo (complete inhibition of IGF-1R-dependent tumor cell growth at 20 mg/kg/12 hr, i.p., in SCID mice) with minimum toxic effect (LD50 > 500 mg/kg). Exhibits little effect towards IR, FGFR, PDGFR and EGFR, and exerts no effects on microtubules and DNA topoisomerase II. Targets the phosphorylation of Y1136 in the activation loop and is the first inhibitor reported to discriminate between IGF-1R and IR.
    产品目录编号 407247
    品牌系列 Calbiochem®
    同义词 Insulin-like Growth Factor-1 Receptor Inhibitor, Picropodophyllin
    参考
    参考 Mazitschek, R., and Giannis, A. 2004. Curr. Opin. Chem. Biol. 8, 432.
    Vasilcanu, D., et al. 2004. Oncogene 23, 7854.
    Girnita, A., et al. 2004. Cancer Res. 64, 236.
    产品信息
    CAS号 477-47-4
    具有ATP竞争性 N
    形式 Off-white solid
    Hill配方 C₂₂H₂₂O₈
    化学配方 C₂₂H₂₂O₈
    Molar Mass 414.4
    可逆 Y
    结构配方图像
    生物信息
    主靶 IGF-1R both in vitro and in vivo
    主靶IC50 1 nM against IGF-1R in cell-free kinase assay; ≤ 60 nM for cell viability and receptor autophosphorylation in melanoma cell lines
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Carcinogenic / Teratogenic
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Unstable in solution at room temperature.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,407247,IGF-1R Inhibitor, PPP - CAS 477-47-4 - Calbiochem

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