merck millipore,默克密理愽
  • merck millipore,默克密理博,217707,Cdc7/Cdk9 Inhibitor - CAS 845714-00-3 - Calbiochem

  • merck millipore,默克密理博,217707,Cdc7/Cdk9 Inhibitor - CAS 845714-00-3 - Calbiochem

    产品名称：Cdc7/Cdk9 Inhibitor - CAS 845714-00-3 - Calbiochem
    产品型号：217707
    The Cdc7/Cdk9 Inhibitor, also referenced under CAS 845714-00-3, controls the biological activity of Cdc7/Cdk9. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation a More>>

    merck millipore,默克密理博,217707,Cdc7/Cdk9 Inhibitor - CAS 845714-00-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,217707,Cdc7/Cdk9 Inhibitor - CAS 845714-00-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₂H₁₁N₃O845714-00-3
    描述
    概述 A cell-permeable pyrrolopyridinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of Cdc7 and Cdk9 (IC50 = 10 and 34 nM, respectively) with good selectivity over a panel of 31 other kinases, including GSK-3β, Cdk2, Cdk1, Cdk5, MK-2, Plk1, and Chk2 (IC50 = 0.22, 0.24, 0.25, 0.46, 0.47, 0.98, and 1.1 µM, respectively). Cellular treatment of PHA76749 results in a prevention of the activation of DNA replication origins without the inhibition of replication fork progression. Shown to inhibit the proliferation of 61 cell lines in vitro (IC50 ≤ 10 µM) and exhibit antitumor activity in both mice and rats in vivo.
    产品目录编号 217707
    品牌系列 Calbiochem®
    同义词 2-(Pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridinone, PHA-767491, Chk2 Inhibitor VI
    参考
    参考 Montagnoli, A., et al. 2008. Nat Chem Biol. 4, 357.
    Vanotti, E., et al. 2008. J. Med. Chem. 51, 487.
    Anderson, D.R., et al. 2007. J. Med. Chem. 50, 2647.
    产品信息
    CAS号 845714-00-3
    形式 Pink solid
    Hill配方 C₁₂H₁₁N₃O
    化学配方 C₁₂H₁₁N₃O
    Molar Mass 213.2
    结构配方图像
    生物信息
    纯度 ≥90% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,217707,Cdc7/Cdk9 Inhibitor - CAS 845714-00-3 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,14-561M,EphB3 Protein, active, 250 µg


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