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merck millipore,默克密理博,420141,JAK2 Inhibitor V, Z3 - CAS 195371-52-9 - Calbiochem
产品名称：JAK2 Inhibitor V, Z3 - CAS 195371-52-9 - Calbiochem
产品型号：420141
The JAK2 Inhibitor V, Z3, also referenced under CAS 195371-52-9, controls the biological activity of JAK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation appli More>>
merck millipore,默克密理博,420141,JAK2 Inhibitor V, Z3 - CAS 195371-52-9 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₃H₂₄N₂O 195371-52-9 描述 概述 A cell-permeable pyridinylbutanone compound that inhibits cellular autophosphorylation of both the wild-type Jak2 and the constitutively active V167F mutant (IC50 = 15 & 28 µM, respectively, with WT- & V617F-transfected BSC-40 cells), while exhiting no effect against cellular Tyk2 autophosphorylation in COS cells or c-Src kinase in cell-free kinase assays. Z3 suppresses the Jak2-V167F-dependent proliferation of the erythroleukemia cell line HEL by blocking the G 1-S transition and is shown to effectively reduce the cytokine-stimulated growth of both Jak2-V617F-positive and Jak2-F537I-positive primary hematopoietic progenitor cells from myeloproliferative disorder patients. 产品目录编号 420141 品牌系列 Calbiochem®
同义词 2-Methyl-1-phenyl-4-pyridin-2-yl-2-(2-pyridin-2-ylethyl)butan-1-one 参考 参考 Sayyah, J., et al. 2008. Mol. Cancer Ther. 7, 2308. 产品信息 CAS号 195371-52-9 形式 Colorless oil Hill配方 C₂₃H₂₄N₂O 化学配方 C₂₃H₂₄N₂O Molar Mass 344.5 吸湿 Hygroscopic
结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 DMSO or EtOH 安全信息 S相 S: 24/25-36
Avoid contact with skin and eyes.
Wear suitable protective clothing.储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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