• merck millipore,默克密理博,420129,JNK Inhibitor V - CAS 345987-15-7 - Calbiochem
  • merck millipore,默克密理博,420129,JNK Inhibitor V - CAS 345987-15-7 - Calbiochem

    产品名称:JNK Inhibitor V - CAS 345987-15-7 - Calbiochem
    产品型号:420129
    The JNK Inhibitor V, also referenced under CAS 345987-15-7, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation application More>>

    merck millipore,默克密理博,420129,JNK Inhibitor V - CAS 345987-15-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,420129,JNK Inhibitor V - CAS 345987-15-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₀H₁₆N₆S345987-15-7
    描述
    概述 A cell-permeable pyrimidinyl compound that displays anti-inflammatory properties. Acts as a potent, reversible, and ATP-competitive inhibitor of c-Jun N-terminal kinase (JNK, IC50 = 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively) with a 10- to 100-fold greater selectivity over a panel of 25 other commonly studied kinases (IC50 typically in the range of 1-10 µM or no effect at 10 µM). Its in vivo efficacy has been demonstrated in gerbils, mice, and rats via oral, i.v., or i.p. administration.
    产品目录编号 420129
    品牌系列 Calbiochem®
    同义词 SAPK Inhibitor V, 1,3-Benzothiazol-2-yl-(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile, AS601245
    参考
    参考 Gaillard, P., et al. 2005. J. Med. Chem. 48, 4596.
    Carboni, S., et al. 2005. J. Neurochem. 92, 1054.
    Ferrandi, C., et al. 2004. Br. J. Pharmacol. 142, 953.
    Carboni, S., et al. 2004. J. Pharm. Exp. Ther. 310, 25.
    产品信息
    CAS号 345987-15-7
    具有ATP竞争性 Y
    形式 Yellow solid
    Hill配方 C₂₀H₁₆N₆S
    化学配方 C₂₀H₁₆N₆S
    Molar Mass 372.5
    吸湿 Hygroscopic
    可逆 Y
    结构配方图像
    生物信息
    主靶 hJNK 1, hJNK 2, hJNK 3
    主靶IC50 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively
    纯度 ≥95% by HPLC (sum of two isomers)
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    储存 -20°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,420129,JNK Inhibitor V - CAS 345987-15-7 - Calbiochem

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