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merck millipore,默克密理博,420129,JNK Inhibitor V - CAS 345987-15-7 - Calbiochem
产品名称:JNK Inhibitor V - CAS 345987-15-7 - Calbiochem
产品型号:420129
The JNK Inhibitor V, also referenced under CAS 345987-15-7, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation application More>>
merck millipore,默克密理博,420129,JNK Inhibitor V - CAS 345987-15-7 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₀H₁₆N₆S 345987-15-7 描述 概述 A cell-permeable pyrimidinyl compound that displays anti-inflammatory properties. Acts as a potent, reversible, and ATP-competitive inhibitor of c-Jun N-terminal kinase (JNK, IC50 = 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively) with a 10- to 100-fold greater selectivity over a panel of 25 other commonly studied kinases (IC50 typically in the range of 1-10 µM or no effect at 10 µM). Its in vivo efficacy has been demonstrated in gerbils, mice, and rats via oral, i.v., or i.p. administration. 产品目录编号 420129 品牌系列 Calbiochem®
同义词 SAPK Inhibitor V, 1,3-Benzothiazol-2-yl-(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile, AS601245 参考 参考 Gaillard, P., et al. 2005. J. Med. Chem. 48, 4596.
Carboni, S., et al. 2005. J. Neurochem. 92, 1054.
Ferrandi, C., et al. 2004. Br. J. Pharmacol. 142, 953.
Carboni, S., et al. 2004. J. Pharm. Exp. Ther. 310, 25.产品信息 CAS号 345987-15-7 具有ATP竞争性 Y 形式 Yellow solid Hill配方 C₂₀H₁₆N₆S 化学配方 C₂₀H₁₆N₆S Molar Mass 372.5 吸湿 Hygroscopic
可逆 Y 结构配方图像 生物信息 主靶 hJNK 1, hJNK 2, hJNK 3 主靶IC50 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively 纯度 ≥95% by HPLC (sum of two isomers) 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Harmful
储存 -20°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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