merck millipore,默克密理愽
  • merck millipore,默克密理博,324631,Eg5 Inhibitor VII - CAS 912953-25-4 - Calbiochem

  • merck millipore,默克密理博,324631,Eg5 Inhibitor VII - CAS 912953-25-4 - Calbiochem

    产品名称：Eg5 Inhibitor VII - CAS 912953-25-4 - Calbiochem
    产品型号：324631
    The Eg5 Inhibitor VII, also referenced under CAS 912953-25-4, controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Cell Structure applications.

    merck millipore,默克密理博,324631,Eg5 Inhibitor VII - CAS 912953-25-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,324631,Eg5 Inhibitor VII - CAS 912953-25-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₆H₁₂F₃NO912953-25-4
    描述
    概述 A cell-permeable quinolinone compound that acts as a highly potent and selective Eg5/KSP inhibitor (Ki = 1.4, 2.1, 2.2, and 1.7 nM for the mutant A133D, KHC-L5, D130V, and the wild-type KSP, respectively) by antagonizing ATP binding via an allosteric site. Effectively induces monopolar spindles in ovarian adenocarcinoma SKOV3 cells and inhibits the proliferation of colorectal carcinoma HCT116 cells (IC50 = 36 and 0.5 nM againt the parental and the ispinesib-resistant D130V mutant line, respectively). It is uncompetitive with respect to microtubule and exhibits little activity against a panel of 7 other mitotic kinesins.
    产品目录编号 324631
    品牌系列 Calbiochem®
    同义词 GSK-1, KSP Inhibitor VII; 6-(4-Trifluoromethyl)phenyl)-3,4-dihydro-2(1H)-quinolinone
    参考
    参考 Luo, L., et al. 2007. Nat. Chem. Biol. 3, 722.
    产品信息
    CAS号 912953-25-4
    形式 Off-white powder
    Hill配方 C₁₆H₁₂F₃NO
    化学配方 C₁₆H₁₂F₃NO
    Molar Mass 291.3
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,324631,Eg5 Inhibitor VII - CAS 912953-25-4 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,ABC396,Anti-CES1 Antibody
下一件merck millipore产品：merck millipore,默克密理博,567440,Sodium Chloride - CAS 7647-14-5 - Calbiochem


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