merck millipore,默克密理愽
  • merck millipore,默克密理博,412512,IRE1 Inhibitor III, 4μ8C - CAS 14003-96-4 - Calbiochem

  • merck millipore,默克密理博,412512,IRE1 Inhibitor III, 4μ8C - CAS 14003-96-4 - Calbiochem

    产品名称：IRE1 Inhibitor III, 4μ8C - CAS 14003-96-4 - Calbiochem
    产品型号：412512
    The IRE1 Inhibitor III, 4µ8C, also referenced under CAS 14003-96-4, controls the biological activity of IRE1.

    merck millipore,默克密理博,412512,IRE1 Inhibitor III, 4μ8C - CAS 14003-96-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,412512,IRE1 Inhibitor III, 4μ8C - CAS 14003-96-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₁H₈O₄14003-96-4
    描述
    概述 A cell-permeable coumarin o-hydroxyaldehyde that inhibits IRE1 RNase activity in a time- and dose-dependent manner (IC50 = 550 and 45 nM, respectively, with 0 and 16 min drug preincubation in RNA cleavage assays) by covalently targeting IRE1 Lys907 via Schiff base formation, effectively preventing ER stress-induced site-specific mRNA splicing as well as RIDD (Regulated IRE1-Dependent Degradation) mRNA degradation (IC50 = 6.9 and 4.1 µM, respectively, against Xbp1 splicing and Scara3 degradation) in MEF cultures following Tunicamycin (Cat. No. 654380) treatment. Comparing to STF083010 (Cat. No. 412510), 4μ8C is also shown to inhibit IRE1 autophosphorylation in cell-free assays via Schiff base formation with IRE1 Lys599 in the absence of ADP, however cellular nucleotide prevents 4μ8C from targeting IRE1 Lys599 intracellularly.
    产品目录编号 412512
    品牌系列 Calbiochem®
    同义词 8-Formyl-7-hydroxy-4-methylcoumarin, 7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde, ER-to-Nucleus Signaling 1 Inhibitor III, Inositol-Reguiring Protein 1 Inhibitor III
    参考
    参考 Cross, B.C.S., et al. 2012. Proc. Natl. acad. Sci. USA 109, E869.
    产品信息
    CAS号 14003-96-4
    形式 Yellow powder
    Hill配方 C₁₁H₈O₄
    Molar Mass 204.2
    可逆 Y
    结构配方图像
    生物信息
    主靶 IRE1
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,412512,IRE1 Inhibitor III, 4μ8C - CAS 14003-96-4 - Calbiochem

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