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- 体外诊断/OEM材料和试剂
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描述 产品目录编号 CBL163-KC 品牌系列 Chemicon®
商名 - Chemicon
描述 Mouse Anti-Human CD33, clone WM53 (1mg) KC 概述 This product is intended for use by IVD manufacturers. Alternate Names - gp67
产品信息 格式 Purified 演示 The monoclonal is presented at a concentration of 100μg/1ml in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application. 应用 主要应用 - Immunohistochemistry
- Flow Cytometry
- Western Blotting
应用说明 Phenotyping of leukaemias, useful in distinguishing myelogenous leukaemias from lymphoid or erythroid leukaemias
Bone marrow purging in autologous bone marrow transplantation
Optimal working dilutions must be determined by the end user.生物信息 克隆 WM53 宿主 Mouse 特异性 The antigen is a single chain transmembrane glycoprotein of molecular mass 67 kDa expressed on monocytes, myeloid progenitor cells and myeloid leukaemias. The antigen has homology with CD22 and myelin associated glycoprotein. 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_001772.3
- NM_001082618.1
基因符号 - SIGLEC-3
- CD33
- gp67
- Siglec-3
- SIGLEC3
- FLJ00391
- p67
UniProt编号 - P20138
UniProt汇总 FUNCTION: SwissProt: P20138 # Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
SIZE: 364 amino acids; 39825 Da
SUBUNIT: Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Monocytic/myeloid lineage cells.
DOMAIN: SwissProt: P20138 Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.
PTM: Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6.
SIMILARITY: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. & Contains 1 Ig-like C2-type (immunoglobulin-like) domain. & Contains 1 Ig-like V-type (immunoglobulin-like) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C. 包装信息 数量 Bulk packaging. Please inquire.
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