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merck millipore,默克密理博,406170,IP6K Inhibitor - CAS 519178-28-0 - Calbiochem
产品名称：IP6K Inhibitor - CAS 519178-28-0 - Calbiochem
产品型号：406170
The IP6K Inhibitor, also referenced under CAS 519178-28-0, controls the biological activity of IP6K.
merck millipore,默克密理博,406170,IP6K Inhibitor - CAS 519178-28-0 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₀H₁₆F₃N₇O₂ 519178-28-0 描述 概述 A cell-permeable 2,6-disubstituted purine compound that, although originally identified as a reversible, ATP-competitive inhibitor against the conversion of Ins(1,4,5)P3 (Cat. Nos. 407123 & 407137) to Ins(1,3,4,5)P4 (Cat. No. 407126) by IP3K (IC50 = 18 µM; [ATP] = 10 μM), acts in fact as a much more effective inhibitor against the IP6K1/2/3-catalyzed conversion of InsP6 (Cat. No. 407125) to 5-[PP]- InsP6 or InsP7 (IC50 = 0.47 μM against IP6K1; [ATP] = 1 mM) due to a much higher affinity of ATP toward IP3K than IP6K (Km of ATP for the respective enzymes = 0.01 vs 1000 μM). Shown to potently inhibit cellular InsP7 level (IC50 = 0.55 μM in HeLa cultures), while being less potent in increasing the cellular InsP3 accumulation (>10 µM in HeLa cultures). TNP is also effective against S. cerevisiae IP6K, Kcs1, but not Vip/PPIP5Ks, enzymes that catalyze the pyrophosphorylation at the 1/3 position of InsP6 and InsP7, in either human or yeast species or two other IP3 metabolizing enzymes, PLC and IP3 5-ppase. 产品目录编号 406170 品牌系列 Calbiochem®
同义词 N²-(m-Trifluorobenzyl), N⁶-(p-nitrobenzyl)purine, Inositol-1,4,5-trisphosphate 3-Kinase Inhibitor, IP3K Inhibitor, Kcs1 Inhibitor, TNP 参考 参考 Padmanabhan, U., et al. 2009. J. Biol. Chem. 284, 10571. Chang, Y.T., et al. 2002. ChemBioChem 3, 897. 产品信息 CAS号 519178-28-0 具有ATP竞争性 Y 形式 Yellow solid Hill配方 C₂₀H₁₆F₃N₇O₂ 化学配方 C₂₀H₁₆F₃N₇O₂ Molar Mass 443.4 可逆 Y 结构配方图像 生物信息 主靶 IP 3-K 主靶IC50 0.47 µM against IP6K1; [ATP] = 1 mM; 18 µM against the conversion of Ins(1,4,5)P3 to Ins(1,3,4,5)P4 by IP3K; [ATP] = 10 µM 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO or MeOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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