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merck millipore,默克密理博,565771,InSolution™ γ-Secretase Inhibitor X - Calbiochem
产品名称：InSolution™ γ-Secretase Inhibitor X - Calbiochem
产品型号：565771
The InSolution™ γ-Secretase Inhibitor X controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
merck millipore,默克密理博,565771,InSolution™ γ-Secretase Inhibitor X - Calbiochem
- 产品介绍
重要规格表
经验配方 C₃₉H₅₂N₄O₆ 描述 概述 A cell-permeable hydroxyethylene dipeptide isostere that acts as a highly specific and a potent inhibitor of γ-secretase (Aβtotal IC50 = 17 nM, Aβ40 IC50 = 48 nM, and Aβ42 IC50 = 67 nM in SHSY5Y cells overexpressing spβA4CTF). Binds to presenilin and blocks Notch intracellular domain production. Functions as a transition state analog mimic at the catalytic site of an aspartyl protease, however, it exhibits over 100-fold greater selectivity for γ-secretase than for cathepsin D. 产品目录编号 565771 品牌系列 Calbiochem®
同义词 L-685,458, {1S-Benzyl-4R-[1-(1S-carbamoyl-2-phenethylcarbamoyl)-1S-3-methylbutylcarbamoyl]-2R-hydroxy-5-phenylpentyl}carbamic Acid tert-butyl Ester 参考 参考 Weidemann, A., et al. 2002. Biochemistry 41, 2825.
Doerfler, P., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 9312.
Li, Y.M., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 6138.
Shearman, M.S., et al. 2000. Biochemistry 39, 8698.产品信息 具有ATP竞争性 N 形式 Liquid 配方 A 1 mM (250 µg in 372 µl or 500 µg in 744 µl) solution in DMSO. Hill配方 C₃₉H₅₂N₄O₆ 化学配方 C₃₉H₅₂N₄O₆ Molar Mass 672.9 可逆 N 结构配方图像 生物信息 主靶 Aβtotal 主靶IC50 Aβtotal 17 nM, Aβ40 48 nM, and Aβ42 67 nM in SHSY5Y cells overexpressing spβA4CTF 纯度 ≥90% by HPLC 理化信息 细胞可渗透 Y 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
防潮 Protect from moisture
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-20°C). 包装信息 惰性气体下包装 Packaged under inert gas
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