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merck millipore,默克密理博,401480,IKK Inhibitor III, BMS-345541 - CAS 445430-58-0 - Calbiochem
产品名称：IKK Inhibitor III, BMS-345541 - CAS 445430-58-0 - Calbiochem
产品型号：401480
The IKK Inhibitor III, BMS-345541, also referenced under CAS 445430-58-0, controls the biological activity of IKK. This small molecule/inhibitor is primarily used for Inflammation/Immunology applicati More>>
merck millipore,默克密理博,401480,IKK Inhibitor III, BMS-345541 - CAS 445430-58-0 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₄H₁₇N₅•2CF₃CO₂H 445430-58-0 描述 概述 A cell-permeable quinoxaline compound that displays anti-inflammatory properties. Acts as a potent, selective, and allosteric site-binding inhibitor of IKK-2 (IC50 = ~ 300 nM). Exhibits ~10-fold greater selectivity over IKK-1 (IC50 = ~ 4 µM) and no activity towards IKKε and a panel of more than 15 unrelated protein kinases even at concentrations as high as 100 µM. Inhibits cellular IκBα phosphorylation (IC50 = 4 µM in THP-1 cells) and LPS-induced cytokine production both in vitro (IC50 = 1-5 µM in THP-1 cells) and in vivo (IC50 = 10 mg/kg in mice). Effectively blocks inflammation and joint destruction in a murine arthritis model. 产品目录编号 401480 品牌系列 Calbiochem®
同义词 4-(2ʹ-Aminoethyl)amino-1,8-dimethylimidazo[1,2-a]quinoxaline 参考 参考 Townsend, R.M., et al. 2004. Transplantation 77, 1090.
MacMaster, J.F., et al. 2003. Inflamm. Res. 52, 508.
McIntyre, K.W., et al. 2003. Arthritis Rheum. 48, 2652.
Burke, J. R., et al. 2003. J. Biol. Chem. 278, 1450.产品信息 CAS号 445430-58-0 具有ATP竞争性 N 形式 Off-white solid 配方 Supplied as bis-TFA salt. Hill配方 C₁₄H₁₇N₅•2CF₃CO₂H 化学配方 C₁₄H₁₇N₅•2CF₃CO₂H Molar Mass 483.4 吸湿 Hygroscopic
可逆 N 结构配方图像 生物信息 主靶 IKK-2 主靶IC50 ~300 nM against IKK-2; 4 µM against cellular IκBα phosphorylation in THP-1 cells; 1-5 µM LPS-induced cytokine production in THP-1 cells 纯度 ≥96% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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