merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB4444,Anti-Epithelial Cell Adhesion Molecule (EpCAM) Antibody, clone 8

  • merck millipore,默克密理博,MAB4444,Anti-Epithelial Cell Adhesion Molecule (EpCAM) Antibody, clone 8

    产品名称：Anti-Epithelial Cell Adhesion Molecule (EpCAM) Antibody, clone 8
    产品型号：MAB4444
    This Anti-Epithelial Cell Adhesion Molecule (EpCAM) Antibody, clone 8 is validated for use in FC, IC, WB for the detection of Epithelial Cell Adhesion Molecule (EpCAM).

    merck millipore,默克密理博,MAB4444,Anti-Epithelial Cell Adhesion Molecule (EpCAM) Antibody, clone 8

  • 产品介绍
  • merck millipore,默克密理博,MAB4444,Anti-Epithelial Cell Adhesion Molecule (EpCAM) Antibody, clone 8

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFC, ICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB4444
    描述 Anti-Epithelial Cell Adhesion Molecule (EpCAM) Antibody, clone 8
    Alternate Names
    • tumor-associated calcium signal transducer 1
    • Adenocarcinoma-associated antigen
    • CD326 antigen
    • Cell surface glycoprotein Trop-1
    • Epithelial cell surface antigen
    • Epithelial glycoprotein
    • KS 1/4 antigen
    • Major gastrointestinal tumor-associated protein GA733-2
    • antigen identified by monoclonal antibody AUA1
    • carcinoma-associated antigen GA733-2
    • epithelial cell adhesion molecule
    • human epithelial glycoprotein-2
    • membrane component, chromosome 4, surface marker (35kD glycoprotein)
    背景信息 Epithelial Call Adhesion Molecule (EpCAM, CD326) is a transmembrane glycoprotein of approximately 40 kDa. EpCAM was initially identified as a tumor associated marker having high expression in quickly proliferating epithelial tumors. As such, EpCAM has been of significant interest as a means for tumor diagnosis and therapy. EpCAM is also expressed in normal epithelial cells, but in comparatively lower levels. Preliminary studies limited EpCAM’s function to cell-cell adhesion; however more recent studies indicate it to be involved in diverse processes that include cell migration, cell signaling, differentiation and proliferation.
    产品信息
    格式 Purified
    控制
    • Human embryonic stem cells
    演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 This Anti-Epithelial Cell Adhesion Molecule (EpCAM) Antibody, clone 8 is validated for use in FC, IC, WB for the detection of Epithelial Cell Adhesion Molecule (EpCAM).
    主要应用
    • Flow Cytometry
    • Immunocytochemistry
    • Western Blotting
    应用说明 Flow Cytometry Analysis: 0.5 µg from a previous lot detected Epithelial cell adhesion molecule in human embryonic stem cells.

    Western Blot Analysis: A previous lot was used by an independent laboratory in WB. (Ng, V., et al., 2010)
    生物信息
    免疫原品种 HES-3 Cells (Choo, et al. (2008) Stem Cells. Jun;26(6):1454-63)
    表位 Unknown
    克隆 mab 8
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes epithelial cell adhesion molecule (EpCAM), specifically on undifferentiated human embryonic stem cells.
    同种型 IgG2aκ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_002345.2
    Entrez基因汇总 This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq].
    基因符号
    • hEGP-2
    • EPCAM
    • 17-1A
    • 323/A3
    • CD326
    • CO-17A
    • CO17-1A
    • EGP
    • EGP-2
    • EGP34
    • EGP40
    • ESA
    • Ep-CAM
    • GA733-2
    • HEA125
    • KS1/4
    • KSA
    • Ly74
    • M1S2
    • M4S1
    • MH99
    • MIC18
    • MK-1
    • MOC31
    • TACST-1
    • TACSTD1
    • TROP1
    纯化方法 Protein G purfied
    UniProt编号
    • P16422
    UniProt汇总 FUNCTION: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection.

    SUBUNIT STRUCTURE: Monomer.

    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

    TISSUE SPECIFICTY: This protein is expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinomas.

    SEQUENCE SIMILARITIES: Belongs to the EPCAM family.

    Contains 1 thyroglobulin type-1 domain.
    产品使用声明
    质量保证 Evaluated by Immunocytochemistry in human embryonic stem cells.

    Immunocytochemistry Analysis: 1-10 µg/mL from a previous lot detected epithelial cell adhesion molecule (EpCAM) in human embryonic stem cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB4444,Anti-Epithelial Cell Adhesion Molecule (EpCAM) Antibody, clone 8

上一件merck millipore产品：merck millipore,默克密理博,401480,IKK Inhibitor III, BMS-345541 - CAS 445430-58-0 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,ABN110,Anti-Solute carrier family 17 member 9 (VNUT) Antibody


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