merck millipore,默克密理愽
  • merck millipore,默克密理博,07-2117,Anti-phospho-RSK1/2 Antibody (Ser363) (Turn motif)

  • merck millipore,默克密理博,07-2117,Anti-phospho-RSK1/2 Antibody (Ser363) (Turn motif)

    产品名称：Anti-phospho-RSK1/2 Antibody (Ser363) (Turn motif)
    产品型号：07-2117
    This phospho-RSK1/2 antibody is validated for use in WB for the detection of the phospho-RSK1/2 protein.

    merck millipore,默克密理博,07-2117,Anti-phospho-RSK1/2 Antibody (Ser363) (Turn motif)

  • 产品介绍
  • merck millipore,默克密理博,07-2117,Anti-phospho-RSK1/2 Antibody (Ser363) (Turn motif)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Xn, HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-2117
    描述 Anti-phospho-RSK1/2 Antibody (Ser363) (Turn motif)
    Alternate Names
    • RSK-1
    • Ribosomal protein S6 kinase alpha-1
    • S6K-alpha-1
    • 90 kDa ribosomal protein S6 kinase 1
    • p90-RSK 1
    • p90RSK1
    • p90S6K
    • MAP kinase-activated protein kinase 1a
    • MAPK-activated protein kinase 1a
    • MAPKAP kinase 1a
    • MAPKAPK-1a
    • Ribosomal S6 kinase 1
    背景信息 P90 ribosomal S6 kinase 1 and 2 (RSK1 and RSK2) belong to a family of Ser/Thr kinases that are important for cell cycle, survival, proliferation and other cellular functions. RSK isoforms are made up of two kinase domains and seem to be activated sequentially by a number of phosphorylation events. RSK1 and RSK2 have both been found to be over-expressed in certain cancer types and both could be promising as cancer treatments. RSK2 has recently been implicated in oncogenesis and tumor progression. RSK1 interacts with PKARIalpha through the N-terminal kinase domain and regulates protein kinase A.
    产品信息
    格式 Affinity Purified
    控制
    • EGF treated A431 cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This phospho-RSK1/2 antibody is validated for use in WB for the detection of the phospho-RSK1/2 protein.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human RSK1/2 phosphorylated at (Ser363).
    表位 Phosphorylated Ser363 of the AGC-kinase C-terminus
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes RSK1/2 phosphorylated at (Ser363).
    品种反应性 XenopusHuman
    Species Reactivity Note Demonstrated to react with Human. Predicted to react with Zebra Fish and Xenopus based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_001006666
    Entrez基因汇总 This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signaling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
    基因符号
    • RSK1
    • RPS6KA1
    • MAPKAPK1A
    纯化方法 Affinity purified
    UniProt编号
    • Q15418
    UniProt汇总 FUNCTION: Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.

    CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

    COFACTOR: Magnesium.

    ENZYME REGULATION: Activated by multiple phosphorylations on threonine and serine residues.

    SUBUNIT STRUCTURE: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation.

    PTM: Autophosphorylated on Ser-380, as part of the activation process.

    SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

    Contains 1 AGC-kinase C-terminal domain.

    Contains 2 protein kinase domains.
    产品使用声明
    质量保证 Evaluated by Western Blot in EGF treated A431 cell lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected RSK1/2 on 10 µg of EGF treated A431 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,07-2117,Anti-phospho-RSK1/2 Antibody (Ser363) (Turn motif)

上一件merck millipore产品：merck millipore,默克密理博,SLLG025SS,Millex-LG，0.20 µm，亲水性 PTFE，25 mm，环氧乙烷灭菌
下一件merck millipore产品：merck millipore,默克密理博,401480,IKK Inhibitor III, BMS-345541 - CAS 445430-58-0 - Calbiochem


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