merck millipore,默克密理愽
  • merck millipore,默克密理博,400083,HIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem

  • merck millipore,默克密理博,400083,HIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem

    产品名称：HIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem
    产品型号：400083
    The HIF-1 Inhibitor, also referenced under CAS 934593-90-5, controls the biological activity of HIF-1.

    merck millipore,默克密理博,400083,HIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,400083,HIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₆H₂₉NO₅934593-90-5
    描述
    概述 A cell-permeable amidophenolic compound that inhibits hypoxia-induced HIF-1 transcription activity (IC50 = 0.7 and 2.6 µM using AGS and Hep3B cells, respectively, in a reporter assay) by selectively blocking the hypoxia-induced accumulation of cellular HIF-1α protein, while exhibiting no apparent effect on the cellular level of HIF-1α mRNA or that of HIF-1β protein. Shown to inhibit malate dehydrogenase 2 (MDH2) activity and suppress mitochondrial respiration. Also available as a 25 mM solution in DMSO (Cat. No. 400092).
    产品目录编号 400083
    品牌系列 Calbiochem®
    同义词 3-(2-(4-Adamantan-1-yl-phenoxy)-acetylamino)-4-hydroxybenzoic acid methyl ester, Hypoxia-Inducible Factor-1 Inhibitor, LW6
    参考
    参考 Lee, K., et al., 2013. Angew. Chem. Int. Ed. 52, In press.
    Lee, K. et. al. 2010. Biochem. Pharmacol. 80, 982.
    Lee, K., et al. 2007. J. Med. Chem. 50, 1675.
    产品信息
    CAS号 934593-90-5
    形式 Light beige powder
    Hill配方 C₂₆H₂₉NO₅
    化学配方 C₂₆H₂₉NO₅
    Molar Mass 435.5
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,400083,HIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem

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