merck millipore,默克密理愽
  • merck millipore,默克密理博,382190,Histone Lysine Methyltransferase Inhibitor - CAS 935693-62-2 - Calbiochem

  • merck millipore,默克密理博,382190,Histone Lysine Methyltransferase Inhibitor - CAS 935693-62-2 - Calbiochem

    产品名称：Histone Lysine Methyltransferase Inhibitor - CAS 935693-62-2 - Calbiochem
    产品型号：382190
    The Histone Lysine Methyltransferase Inhibitor, also referenced under CAS 935693-62-2, controls the biological activity of Histone Lysine Methyltransferase. This small molecule/inhibitor is primarily  More>>

    merck millipore,默克密理博,382190,Histone Lysine Methyltransferase Inhibitor - CAS 935693-62-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,382190,Histone Lysine Methyltransferase Inhibitor - CAS 935693-62-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₈H₃₈N₆O₂935693-62-2
    描述
    概述 A cell-permeable diazepinyl-quinazolinamine, non-SAM (S-adenosylmethionine) analog-based HMTase (histone methyltransferase) inhibitor that selectively interferes with the G9a-catalyzed H3K9me2 (histone H3 Lys9 dimethylation) modification (IC50 = 1.7 µM) in a reversible manner. It inhibits the GLP-catalyzed H3K9me3 only at much higher concentrations (IC50 = 38 µM) and exhibits little activity against H3 methylations catalyzed by other HMTases (PRMT1, SET7/9, ESET, SUV39H1). Shown to effectively synergize with Oct3/4 and Klf4 in inducing reprogramming of primary murine fetal NPCs (Neural Progenitor Cells) into iPS (induced Pluripotent Stem) cells without additional viral transduction of Sox2 and c-Myc.
    产品目录编号 382190
    品牌系列 Calbiochem®
    同义词 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-(1-(phenylmethyl)-4-piperidinyl)-4-quinazolinamine, BIX-01294, HMTase Inhibitor, EHMT2/G9a Inhibitor I
    参考
    参考 Shi, Y., et al. 2008. Cell Stem Cell 2, 525.
    Kubicek, S., et al. 2007. Mol. Cell 25, 473.
    产品信息
    CAS号 935693-62-2
    形式 Off-white solid
    Hill配方 C₂₈H₃₈N₆O₂
    化学配方 C₂₈H₃₈N₆O₂
    Molar Mass 490.6
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,382190,Histone Lysine Methyltransferase Inhibitor - CAS 935693-62-2 - Calbiochem

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