merck millipore,默克密理愽
  • merck millipore,默克密理博,448101,Met Kinase Inhibitor - CAS 658084-23-2 - Calbiochem

  • merck millipore,默克密理博,448101,Met Kinase Inhibitor - CAS 658084-23-2 - Calbiochem

    产品名称：Met Kinase Inhibitor - CAS 658084-23-2 - Calbiochem
    产品型号：448101
    The Met Kinase Inhibitor, also referenced under CAS 658084-23-2, controls the biological activity of Met Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation More>>

    merck millipore,默克密理博,448101,Met Kinase Inhibitor - CAS 658084-23-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,448101,Met Kinase Inhibitor - CAS 658084-23-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₈H₃₀ClN₅O₄S658084-23-2
    描述
    概述 A cell-permeable pyrrole indolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of Met kinase activity (IC50 = 20 nM). Exhibits > 60-fold selectivity over Flk and > 400-fold selectivity over Ron, FGFR-1, c-Src, Cdk2, PDGFRβ, EGFR, and Tie-2. Shown to inhibit HGF/SF-stimulated cellular signaling and Met-mediated tumorigenesis in various cancer cell lines.
    产品目录编号 448101
    品牌系列 Calbiochem®
    同义词 (3Z)-N-(3-Chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide, SU11274
    参考
    参考 Ma. P. C., et al. 2005. Cancer Res. 65, 1479.
    Berthou, S., et al. 2004. Oncogene 23, 5387.
    Wang, X., et al. 2003. Mol. Cancer Ther. 2, 1085.
    Sattler, M., et al. 2003. Cancer Res. 63, 5462.
    产品信息
    CAS号 658084-23-2
    具有ATP竞争性 Y
    形式 Orange solid
    Hill配方 C₂₈H₃₀ClN₅O₄S
    化学配方 C₂₈H₃₀ClN₅O₄S
    Molar Mass 568.1
    可逆 Y
    结构配方图像
    生物信息
    主靶 met kinase activity
    主靶IC50 20 nM against Met kinase activity
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,448101,Met Kinase Inhibitor - CAS 658084-23-2 - Calbiochem

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