merck millipore,默克密理愽
  • merck millipore,默克密理博,373400,Hh/Gli Antagonist, GANT58 - CAS 64048-12-0 - Calbiochem

  • merck millipore,默克密理博,373400,Hh/Gli Antagonist, GANT58 - CAS 64048-12-0 - Calbiochem

    产品名称：Hh/Gli Antagonist, GANT58 - CAS 64048-12-0 - Calbiochem
    产品型号：373400
    The Hh/Gli Antagonist, GANT58, also referenced under CAS 64048-12-0, controls the biological activity of Hh/Gli. This small molecule/inhibitor is primarily used for Cell Signaling applications.

    merck millipore,默克密理博,373400,Hh/Gli Antagonist, GANT58 - CAS 64048-12-0 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,373400,Hh/Gli Antagonist, GANT58 - CAS 64048-12-0 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₄H₁₆N₄S64048-12-0
    描述
    概述 A cell-permeable tetrapyridinylthiophene compound that acts as downstream Hedgehog (Hh) pathway blocker and targets Gli-mediated gene transactivation (IC50 ~ 5 µM in SAG-stimulated Shh-L2 cells). Its action appears to be Hh pathway-selective, downstream of Smo and Sufu, but does not seem to interfere with Gli DNA binding. Shown to reduce cellular mRNA levels of Hh target genes, Gli1, Hip1,& Ptch, and inhibit Gli-dependent tumor growth both in vitro and in vivo.
    产品目录编号 373400
    品牌系列 Calbiochem®
    同义词 4-(2,4,5-Tri(pyridin-4-yl)thiophen-3-yl)pyridine, NSC 75503
    参考
    参考 Lauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455.
    产品信息
    CAS号 64048-12-0
    形式 Yellow solid
    Hill配方 C₂₄H₁₆N₄S
    化学配方 C₂₄H₁₆N₄S
    Molar Mass 392.5
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Regulatory Review
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,373400,Hh/Gli Antagonist, GANT58 - CAS 64048-12-0 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,MABN502,Anti-SNAT1 Antibody, clone N104/37


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