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  • merck millipore,默克密理博,06-811,Anti-Na+ Channel α Antibody, cardiac (III-IV loop)

  • merck millipore,默克密理博,06-811,Anti-Na+ Channel α Antibody, cardiac (III-IV loop)

    产品名称：Anti-Na+ Channel α Antibody, cardiac (III-IV loop)
    产品型号：06-811
    This Anti-Na+ Channel α Antibody, cardiac (III-IV loop) is validated for use in IC, IP, WB for the detection of Na+ Channel α.

    merck millipore,默克密理博,06-811,Anti-Na+ Channel α Antibody, cardiac (III-IV loop)

  • 产品介绍
  • merck millipore,默克密理博,06-811,Anti-Na+ Channel α Antibody, cardiac (III-IV loop)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    VrtWB, ICCRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 06-811
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Na+ Channel α Antibody, cardiac (III-IV loop)
    背景信息 Voltage-gated sodium channels in the brain are characterized into three subtypes: brain type I, type II and type III based on function and structure. Antibodies against these subtypes consist of a principle alpha subunit with variable isoforms and two auxiliary subunits termed β1 and β2.
    产品信息
    格式 Purified
    控制
    • Tested on rat brain microsomal lysate
    演示 Purified in PBS with 0.05% NaN3 and 30% Glycerol
    应用
    应用 This Anti-Na+ Channel α Antibody, cardiac (III-IV loop) is validated for use in IC, IP, WB for the detection of Na+ Channel α.
    主要应用
    • Western Blotting
    • Immunocytochemistry
    应用说明 Western Blot: 0.5-2 μg/mL of this lot detected Na+ Channel (III-IV loop) in 20 μg Rat Brain Microsomal Prep. (Catalog # 12-144).

    Immunoprecipitation:
    1-4 μg of a previous lot immunoprecipitated Na+ Channel (III-IV loop) from 400 μg of Rat Brain Microsomal Prep.

    Immunocytochemistry:
    (See photo1) Mouse sciatic nerves stained with cat. # 06-811 at 20 µg/mL.
    生物信息
    宿主 Rabbit
    特异性 sodium channel intracellular III-IV loop
    同种型 IgG
    品种反应性 Vertebrates
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_006920
    Entrez基因汇总 The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, chiefly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large central pore-forming glycosylated alpha subunit and 2 smaller auxiliary beta subunits. Functional studies have indicated that the transmembrane alpha subunit of the brain sodium channels is sufficient for expression of functional sodium channels (Goldin et al., 1986 [PubMed 2429308]; Isom, 2002 [PubMed 11779698]).[supplied by OMIM]
    基因符号
    • SMEI
    • SCN1A
    • HBSCI
    • Nav1.1
    • FEB3
    • NAC1
    • GEFSP2
    • SCN1
    纯化方法 Protein A chromatography
    UniProt编号
    • P35498
    UniProt汇总 FUNCTION: SwissProt: P35498 # Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
    SIZE: 2009 amino acids; 228972 Da
    SUBUNIT: The sodium channel consists of a large polypeptide and 2- 3 smaller ones. This sequence represents a large polypeptide.
    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
    DOMAIN: SwissProt: P35498 The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
    DISEASE: SwissProt: P35498 # Defects in SCN1A are the cause of generalized epilepsy with febrile seizures plus type 2 (GEFS+2) [MIM:604233]. This autosomal dominant disorder is characterized by febrile seizures in children and afebrile seizures in adults. Penetrance is incomplete and a large intrafamilial variability of the phenotype is observed. & Defects in SCN1A are a cause of severe myoclonic epilepsy in infancy (SMEI) [MIM:607208]; also called Dravet syndrome. SMEI is a severe form of generalized epilepsy with febrile seizures. It is a rare disorder characterized by normal development before onset, seizures beginning in the first year of life in the form of generalized or unilateral febrile clonic seizures, secondary appearance of myoclonic seizures, and occasionally partial seizures. It is associated with ataxia, slowed psychomotor development, and mental decline. & Defects in SCN1A are the cause of familial hemiplegic migraine 3 (FHM3) [MIM:609634]. FHM3 is an autosomal dominant severe subtype of migraine with aura characterized by some degree of hemiparesis during the attacks. The episodes are associated with variable features of nausea, vomiting, photophobia and phonophobia. Age at onset ranges from 6 to 15 years. Some patients may manifest seizures during infancy. & Defects in SCN1A are the cause of familial febrile convulsions 3 (FEB3) [MIM:604403]; also known as familial febrile seizures 3. Febrile convulsions affect 5-12% of infants and children up to 6 years of age. There is epidemiological evidence that febrile seizures are associated with subsequent afebrile and unprovoked seizures in 2% to 7% of patients. Inheritance pattern is autosomal dominant.
    SIMILARITY: Belongs to the sodium channel family. & Contains 1 IQ domain.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on Rat Brain Microsomal Prep
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,06-811,Anti-Na+ Channel α Antibody, cardiac (III-IV loop)

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