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merck millipore,默克密理博,373278,Hh Signaling Antagonist XII, MRT-83 - Calbiochem
产品名称：Hh Signaling Antagonist XII, MRT-83 - Calbiochem
产品型号：373278
The Hh Signaling Antagonist XII, MRT-83 controls the biological activity of Hh pathway. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
merck millipore,默克密理博,373278,Hh Signaling Antagonist XII, MRT-83 - Calbiochem
- 产品介绍
重要规格表
经验配方 C₃₁H₃₀N₄O₅ 描述 概述 A cell-permeable acylguanidine compound that is shown to block Hh signaling and act as a potent, reversible and high-affinity Smo (Smoothened) antagonist. Displays 20-60 -fold greater potency than Cyclopamine (Cat. No. 239803) and competitively inhibits bodipy-cyclopamine binding to Smo (IC50 = 4.6 and 14 nM in HEK293-hSMO and HEK293-mSMO cells, respectively). Represses ShhN (N-myristoylated Shh) signaling (IC50 = 15 nM for Gli-dependent luciferase activity in Shh-light2 cells) and SAG-(Cat. Nos. 566660 & 566661) induced C3H10T1/2 cell differentiation (IC50 = 10 nM in an alkaline phosphatase activity assay). Inhibits ShhN (3 nM) and SAG (10 nM)-mediated proliferation of rat cerebellar granule cell precursors (IC50 ~ 3 and 6 nM, respectively). 产品目录编号 373278 品牌系列 Calbiochem®
同义词 N-(2-Methyl-5-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)-(1,1ʹ-biphenyl)-4-carboxamide 参考 参考 Roudaut, H., et al. 2011. Mol. Pharmacol. 79, 453. 产品信息 形式 Yellowish-white solid Hill配方 C₃₁H₃₀N₄O₅ 化学配方 C₃₁H₃₀N₄O₅ Molar Mass 538.6 结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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下一件merck millipore产品：merck millipore,默克密理博,16-243,Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor 488
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