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merck millipore,默克密理博,16-243,Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor 488
产品名称：Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor 488
产品型号：16-243
This Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor 488 is validated for use in FC, IC, WB for the detection of Na+/K+ ATPase α-1.
merck millipore,默克密理博,16-243,Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor 488
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Xn, Ca, H, M, Mk, Po, R, Rb WB, FC, ICC M AlexaFluor®488 Monoclonal Antibody 描述 产品目录编号 16-243 品牌系列 Upstate
商名 - Upstate
描述 Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor® 488 产品信息 格式 AlexaFluor®488 应用 应用 This Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor 488 is validated for use in FC, IC, WB for the detection of Na+/K+ ATPase α-1. 主要应用 - Western Blotting
- Flow Cytometry
- Immunocytochemistry
生物信息 免疫原品种 Purified Na+/K+ ATPase isolated from membrane fractions of rabbit kidney outer medulla. 克隆 clone C464.6 宿主 Mouse 特异性 Specific for the α-1 subunit isoform. 同种型 IgG1κ 品种反应性 XenopusCanineHumanMouseMonkeyPigRatRabbit 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_152296.3
Entrez基因汇总 The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. 基因符号 - +K
- ATP1A3
- RDP
- IIIsubunit).
- MGC13276
- DYT12
- Na
纯化方法 Protein G purfied UniProt编号 - Q9N0Z6
UniProt汇总 FUNCTION: SwissProt: P13637 # This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
SIZE: 1013 amino acids; 111749 Da
SUBUNIT: Composed of three subunits: alpha (catalytic), beta and gamma.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
DISEASE: SwissProt: P13637 # Defects in ATP1A3 are the cause of dystonia-12 (DYT12) [MIM:128235]; also known as rapid-onset dystonia parkinsonism (RDP). DYT12 is an autosomal dominant form of dystonia- parkinsonism characterized by an unusually rapid evolution of signs and symptoms. Affected persons develop dystonia and parkinsonism between 14 and 45 years of age. The sudden onset of symptoms over hours to a few weeks, often associated with physical or emotional stress, suggests a trigger initiating a nervous system insult resulting in permanent neurologic disability.
SIMILARITY: SwissProt: P13637 ## Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily.产品使用声明 质量保证 Routinely evaluated by immunoblot. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
- Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
储存和货运信息 存储条件 2 years at 4°C from date of shipment 包装信息 数量 25 µg
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下一件merck millipore产品：merck millipore,默克密理博,513030,PD 169316 - CAS 152121-53-4 - Calbiochem
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