merck millipore,默克密理博,371955,H-7, Dihydrochloride - CAS 108930-17-2

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merck millipore,默克密理博,371955,H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem
产品名称：H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem
产品型号：371955
A broad-based, cell-permeable, reversible, ATP-competitive serine/threonine kinase inhibitor.

merck millipore,默克密理博,371955,H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem

产品介绍

merck millipore,默克密理博,371955,H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem

重要规格表

经验配方	CAS号
C₁₄H₁₇N₃O₂S · 2HCl	108930-17-2

描述
概述	A broad-based, cell-permeable, reversible, ATP-competitive serine/threonine kinase inhibitor. Inhibits protein kinase A (K_i = 3.0 µM), myosin light chain kinase (K_i = 97 µM), protein kinase C (K_i = 6.0 µM), and protein kinase G (K_i = 5.8 µM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells.
产品目录编号	371955
品牌系列	Calbiochem®
同义词	1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, 2HCl

参考
参考	Ku, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730. Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707. Bergstrand, H., et al. 1992. J. Pharmacol. Exp. Therap. 263, 1334. Gimond, C., et al. 1992. Exp. Cell Res. 203, 365. Quick, J., et al. 1992. Biochem. Biophys. Res. Commun. 187, 657. Bouli, N.M., and Davis, M. 1990. Brain Res. 525, 198. Takahashi, I., et al. 1990. J. Pharmacol. Exp. Ther. 255, 1218. Schachtele, C., et al. 1988. Biochem. Biophys. Res. Commun. 151, 542. Kawamoto, S., and Hidaka, H. 1984. Biochem. Biophys. Res. Commun. 125, 258.

参考

Ku, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730.
Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
Bergstrand, H., et al. 1992. J. Pharmacol. Exp. Therap. 263, 1334.
Gimond, C., et al. 1992. Exp. Cell Res. 203, 365.
Quick, J., et al. 1992. Biochem. Biophys. Res. Commun. 187, 657.
Bouli, N.M., and Davis, M. 1990. Brain Res. 525, 198.
Takahashi, I., et al. 1990. J. Pharmacol. Exp. Ther. 255, 1218.
Schachtele, C., et al. 1988. Biochem. Biophys. Res. Commun. 151, 542.
Kawamoto, S., and Hidaka, H. 1984. Biochem. Biophys. Res. Commun. 125, 258.

产品信息
CAS号	108930-17-2
具有ATP竞争性	Y
形式	Light yellow lyophilized solid
Hill配方	C₁₄H₁₇N₃O₂S · 2HCl
化学配方	C₁₄H₁₇N₃O₂S · 2HCl
Molar Mass	364.3
可逆	Y
结构配方图像

生物信息
主靶	MLCK
主靶K_i	3.0 µM, 97 µM, 6.0 µM, 5.8 µM against protein kinase A , myosin light chain kinase, protein kinase C , and protein kinase G, respectively
纯度	≥98% by TLC

理化信息
细胞可渗透	Y
溶解度	H₂O

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.