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经验配方 CAS号 C₂₁H₃₄O₂ 516-54-1 描述 概述 A natural metabolite of progesterone that is devoid of any progestational activity. Acts as a potent ligand of GABA type A receptor complexes in the CNS. Potentiates the GABA receptor-mediated chloride uptake in synaptosomes 100- to 1,000-fold more effectively than benzodiazepines or barbiturates. Causes a rapid increase in Ca2+ influx in a dose-dependent manner (EC50 =10 nM in fetal hypothalamic neurons). 产品目录编号 127100 品牌系列 Calbiochem®
同义词 Allopregnan-3α-ol-20-one, 3α-Hydroxy-5α-pregnan-20-one, 3α-OH-DHP 参考 参考 Dayanithi, G., and Tapia-Arancibia, L. 1996. J. Neurosci. 16, 130.
Bitran, P., et al. 1995. J. Neuroendocrinol. 7, 171.
Calixto, E., et al. 1995. Neurosci. Lett. 195, 73.
Genazzani, A.R., et al. 1995. Eur. J. Endocrinol. 133, 375.
Paul, S.M., and Purdy, R.H. 1992. FASEB J. 6, 2311.
Zaman, S.H., et al. 1992. Eur. J. Pharmacol. 225, 321.
McEwan, B.S. 1991. Trends Pharmacol. Sci. 12, 141.产品信息 CAS号 516-54-1 具有ATP竞争性 N 形式 White solid Hill配方 C₂₁H₃₄O₂ 化学配方 C₂₁H₃₄O₂ Molar Mass 318.5 可逆 N 结构配方图像 生物信息 主靶 Potent ligand of GABA type A receptor complexes in the CNS 主靶IC50 EC50 =10 nM causing a rapid increase in Ca2+ influx in a dose-dependent manner in fetal hypothalamic neurons 纯度 ≥95% by HPLC 理化信息 细胞可渗透 N 溶解度 DMSO or EtOH GHS安全信息 RTECS TU4383000 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +15°C to +30°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
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