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merck millipore,默克密理博,435300,LFM-A13 - CAS 62004-35-7 - Calbiochem
产品名称：LFM-A13 - CAS 62004-35-7 - Calbiochem
产品型号：435300
A potent, cell-permeable, reversible, substrate competitive, and specific inhibitor of Bruton's Tyrosine Kinase (BTK; IC₅₀ = 17.2 µM for human BTK in vitro and IC₅₀ = 2.5 µM for recombinant BTK More>>
merck millipore,默克密理博,435300,LFM-A13 - CAS 62004-35-7 - Calbiochem
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重要规格表
经验配方 CAS号 C₁₁H₈Br₂N₂O₂ 62004-35-7 描述 概述 A potent, cell-permeable, reversible, substrate competitive, and specific inhibitor of Bruton’s Tyrosine Kinase (BTK; IC50 = 17.2 µM for human BTK in vitro and IC50 = 2.5 µM for recombinant BTK). Also inhibits Polo-like kinase in an ATP-competitive manner (IC50 = 10 µM and 61 µM for Plx1 and Plk3, respectively), and displays antitumor properties. Does not affect the enzymatic activity of other protein tyrosine kinases, including EGFR, HCK, IRK JAK1, and JAK3 even at concentrations of 278 µM. Enhances the chemosensitivity of BTK-positive B-lineage leukemia cells to ceramide- and vincristine-induced apoptosis. 产品目录编号 435300 品牌系列 Calbiochem®
同义词 α-Cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide, BTK Inhibitor I, Bruton's Tyrosine Kinase Inhibitor I 参考 参考 Uckun, F.M., et al. 2006. Bioorg. Med. Chem. In press.
Mahajan, S., et al. 1999. J. Biol. Chem. 274, 9587.
Vassilev, A., et al. 1999. J. Biol. Chem. 274, 1646.产品信息 CAS号 62004-35-7 具有ATP竞争性 Y 形式 Light brown solid Hill配方 C₁₁H₈Br₂N₂O₂ 化学配方 C₁₁H₈Br₂N₂O₂ Molar Mass 360.0 可逆 Y 结构配方图像 生物信息 主靶 Human Bruton's Tyrosine Kinase (BTK) 主靶IC50 17.2 µM for human BTK in vitro and 2.5 µM for recombinant BTK 纯度 ≥97% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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