merck millipore,默克密理博,362331,GAG Agonist, Adhesamine

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Merck Millipore 默克密理愽

merck millipore,默克密理博,362331,GAG Agonist, Adhesamine - Calbiochem

经验配方
C₂₈H₃₂Cl₂F₆N₈O₆S₂

描述
概述	A symmetrical nonpeptidyl cationic diaryldispirotripiperazine compound that binds GAGs (glycosaminoglycans) in a reversible manner (K_D = 0.39, 4.67, and 5.85 µM for heparin, heparan sulfate, and keratin sulfate, respectively) and effectively promotes adhesion (by ~100 and 600% at 60 µM, respectively) and growth (by ~80 and 50% in 72 h at 1 µM, respectively) of HepG2 and Jurkat cells in a dose-dependent manner. Binding studies using heparin-derived oligosaccharides indicate that the major mode of interaction involves the binding of a hexasaccharide unit by two adhesamine molecules (K_D = 0.12 µM). Primary murine hippocampal neurons cultured in the presence of adhesamine are reported to exhibit earlier differentiation as well as improved survival rate when compared with neurons cultured on poly-L-lysine-coated surface. A GAGs binding antagonist Surfen is also available under Cat. No. 362330.
产品目录编号	362331
品牌系列	Calbiochem®
同义词	Glycosaminoglycans Agonist

参考
参考	Hoshino, M., et al. 2010. Biochem. J. 427, 297. Yamazoe, S., et al. 2009. Chem. Biol. 16, 773.

生物信息
纯度	≥80% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性	Standard Handling
储存	-20°C
避光	Protect from light
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,362331,GAG Agonist, Adhesamine - Calbiochem

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