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merck millipore,默克密理博,AB5589-200UL,Anti-Potassium Channel Kv1.3 Antibody, extracellular domain
产品名称：Anti-Potassium Channel Kv1.3 Antibody, extracellular domain
产品型号：AB5589-200UL
This Anti-Potassium Channel Kv1.3 Antibody, extracellular domain is validated for use in FC, WB for the detection of Potassium Channel Kv1.3.
merck millipore,默克密理博,AB5589-200UL,Anti-Potassium Channel Kv1.3 Antibody, extracellular domain
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H WB, FC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5589-200UL 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Potassium Channel Kv1.3 Antibody, extracellular domain 产品信息 格式 Affinity Purified 控制 - Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). For negative control, preincubate 5 μg of purified peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
演示 Affinity purified immunoglobulin. Lyophilized from PBS, pH 7.4, containing 1% BSA and 0.05% sodium azide. Reconstitute with 200 μL of sterile distilled water. Centrifuge antibody preparation before use (10,000 x g for 5 min). 应用 应用 This Anti-Potassium Channel Kv1.3 Antibody, extracellular domain is validated for use in FC, WB for the detection of Potassium Channel Kv1.3. 主要应用 - Western Blotting
- Flow Cytometry
应用说明 Western blotting: 1:200-1:500 using ECL on rat brain membranes.
Indirect flow cytometry: 0.5-5 μg of antibody per 1x10e6cells.
Dilutions should be made using a carrier protein such as BSA (1-3%).
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Highly purified peptide corresponding to residues 211-224 of human Kv1.3 (Accession P22001). 表位 extracellular domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes Kv1.3, extracellular (Kcna3). 品种反应性 RatHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002232.3
Entrez基因汇总 Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. 基因符号 - PCN3
- KCNA3
- HLK3
- HGK5
- KV1.3
- HuKIII
- HPCN3
- Kv1.3
- MK3
- HUKIII
UniProt编号 - P22001
UniProt汇总 FUNCTION: SwissProt: P22001 # Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
SIZE: 523 amino acids; 58304 Da
SUBUNIT: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
DOMAIN: SwissProt: P22001 The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. & The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
SIMILARITY: Belongs to the potassium channel family. A (Shaker) subfamily.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material at -20°C for up to 6 months after date of receipt. After reconstitution maintain antibody and control peptide at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 200 µL
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