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品种反应性 主要应用 宿主 格式 抗体类型 M WB, ELISA Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB3402P 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Agouti Related Protein Antibody Alternate Names - AGRP
背景信息 Agouti-related peptide-expressing (AgRP) neurons seem to be critical for the acute regulation of eating. The AgRP ptrotein is a strong antagonis of MC3-R and MC4-R and is expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney. 产品信息 格式 Affinity Purified 演示 Liquid in phosphate buffered saline containing 0.1% BSA. 应用 应用 Detect Agouti Related Protein using this Anti-Agouti Related Protein Antibody validated for use in ELISA & WB. 主要应用 - Western Blotting
- ELISA
应用说明 Western blot: 1-10 μg/mL using ECL.
ELISA: 1:10,000-1:50,000 using 50-100 ng control peptide per well.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 A 15 amino acid peptide near the C-terminus of mouse AGRP (Shutter et al. 1997; Ollmann et al. 1997). 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes AGRP. The immunogen shows no significant sequence homology with Agouti, tubby, tub, TULP1 or TULP2.
SPECIES REACTIVITIES: The immunogen sequence is 85% homologous with human and bovine. Reactivity with other species has not been confirmed.品种反应性 Mouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_007316.1
- NM_001138.1
Entrez基因汇总 Agouti-related protein is an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation. Agouti-related protein is alternatively spliced into 2 variants which differ in 5' untranslated sequence length. 基因符号 - ART
- AGRP
- Agrt
- ASIP2
- MGC118963
- AGRT
UniProt编号 - O00253
UniProt汇总 FUNCTION: SwissProt: O00253 # Plays a role in weight homeostasis. May play a role in the regulation of melanocortin receptors within the hypothalamus and adrenal gland, and therefore in the central control of feeding.
SIZE: 132 amino acids; 14440 Da
SUBCELLULAR LOCATION: Secreted (By similarity).
TISSUE SPECIFICITY: Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
DOMAIN: SwissProt: O00253 The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
DISEASE: SwissProt: O00253 # Defects in AGRP may be a cause of autosomal dominant obesity [MIM:601665].
SIMILARITY: Contains 1 agouti domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µg
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