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品种反应性 主要应用 宿主 格式 抗体类型 Rb, H, M, R WB, EMSA Rb Purified Polyclonal Antibody 描述 产品目录编号 07-107 品牌系列 Upstate
商名 - Upstate
描述 Anti-Sp3 Antibody 背景信息 The sequence-specific transcription factor Sp3 binds GC and GT box sequences in the promoters of a variety of genes. The Sp3 transcription factor contains three zinc finger domains that determine sequence specificity of DNA binding. This transcription factor is thought to regulate nucleoside, nucleotide and nucleic acid metabolism and many other “housekeeping” genes. Sp3 can be modified by sumoylation by Ubc9 and has been shown to interact with other transcription factors and histonbe deacetylases. Sp3 has been reported to act as a transcriptional enhancer and repressor of Sp1 activity in a cell- and context-dependent manner. 产品信息 格式 Purified 控制 - Raji cell nuclear extract
演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Detect Sp3 with Anti-Sp3 Antibody (Rabbit Polyclonal Antibody), that has been shown to work in EMSA, IP & WB. 主要应用 - Western Blotting
- Electrophoretic Mobility Shift Assay
生物信息 免疫原品种 Fusion protein corresponding to amino acid residues 239-653 of human Sp3 宿主 Rabbit 特异性 Sp3 isoforms 同种型 IgG 品种反应性 RabbitHumanMouseRat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_003111
Entrez基因汇总 This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. 基因符号 - SPR-2
- SP3
- DKFZp686O1631
纯化方法 Protein A chromatography UniProt编号 - Q02447
UniProt汇总 FUNCTION: SwissProt: Q02447 # Transcriptional factor that can act as an activator or repressor, probably in a isoform-specific manner. Binds to GT and GC boxes promoters elements.
SIZE: 781 amino acids; 81925 Da
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Ubiquitously expressed.
SIMILARITY: SwissProt: Q02447 ## Belongs to the Sp1 C2H2-type zinc-finger protein family. & Contains 3 C2H2-type zinc fingers.产品使用声明 质量保证 routinely evaluated by immunoblot on Raji nuclear extract or HeLa nuclear extract 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
上一件merck millipore产品：merck millipore,默克密理博,OP107,Anti-BRCA1 (Ab-4) Mouse mAb (SD118)
下一件merck millipore产品：merck millipore,默克密理博,PC16,Anti-FGF, Basic (Ab-2) (40-63) Rabbit pAb
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