merck millipore,默克密理愽
  • merck millipore,默克密理博,347423,β-Glucuronidase Inhibitor - Calbiochem

  • merck millipore,默克密理博,347423,β-Glucuronidase Inhibitor - Calbiochem

    产品名称：β-Glucuronidase Inhibitor - Calbiochem
    产品型号：347423
    The β-Glucuronidase Inhibitor controls the biological activity of β-Glucuronidase.

    merck millipore,默克密理博,347423,β-Glucuronidase Inhibitor - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,347423,β-Glucuronidase Inhibitor - Calbiochem

    重要规格表

    经验配方
    C₂₃H₂₇N₃O₃S
    描述
    概述 An orally bioavailable trisubstituted thiourea compound that acts as a potent, uncompetitive and reversible inhibitor of bacterial β-glucuronidase activity (IC50 = 283 nM; kcat/Km = 0.0987 s-1µM-1; Ki = 164 nM in vitro assays against E coli β-glucuronidase; EC50 = 17.7 nM in β-glucuronidase expressing HB101 cells) with excellent selectivity over mammalian β-glucuronidases. Shown to directly target the 17-residue (360-376) loop structure that protects the active site of E coli β-glucuronidase and alter its conformation. Displays negligible cytotoxicity toward both bacterial and mammalian epithelial cells (>> 100 µM for HCT116, Caco-2 and CMT93 colon cancer cells) and offers protection against CPT-11 (50 mg/kg, i.p., s.i.d. for 9 days)-induced toxicity in mice (10 µg, p.o., b.i.d).
    产品目录编号 347423
    品牌系列 Calbiochem®
    同义词 1-((6,8-Dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(4-ethoxyphenyl)-1-(2-hydroxyethyl)thiourea
    参考
    参考 Wallace, B.D., et al. 2010. Science 330, 831.
    产品信息
    形式 White solid
    Hill配方 C₂₃H₂₇N₃O₃S
    化学配方 C₂₃H₂₇N₃O₃S
    Molar Mass 425.5
    结构配方图像
    生物信息
    纯度 ≥99% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,347423,β-Glucuronidase Inhibitor - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,07-2174,Anti-Heat Shock Protein 90α Antibody
下一件merck millipore产品：merck millipore,默克密理博,17-320,Histone Deacetylase Assay Kit (HDAC)


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