merck millipore,默克密理愽
  • merck millipore,默克密理博,219331,β-Catenin/Tcf Inhibitor II, PKF118-310 - Calbiochem

  • merck millipore,默克密理博,219331,β-Catenin/Tcf Inhibitor II, PKF118-310 - Calbiochem

    产品名称：β-Catenin/Tcf Inhibitor II, PKF118-310 - Calbiochem
    产品型号：219331
    The β-Catenin/Tcf Inhibitor II, PKF118-310 controls the biological activity of β-Catenin/Tcf. This small molecule/inhibitor is primarily used for Cancer applications.

    merck millipore,默克密理博,219331,β-Catenin/Tcf Inhibitor II, PKF118-310 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,219331,β-Catenin/Tcf Inhibitor II, PKF118-310 - Calbiochem

    重要规格表

    经验配方
    C₇H₇N₅O₂
    描述
    概述 A synthetic cell-permeable actinobacteria pyrimidotriazine-dione that selectively disrupts β-catenin-Tcf4 interaction (IC50 = 0.8 µM in cell-free binding assays) and inhibits β-catenin-regulated cellular transcription activity (IC50 = 0.3 µM in HCT116-based reporter assays). PKF118-310 is demonstrated to reverse β-catenin, but not siamois, mRNA-induced ventral body axis formation in Xenopus embryos, while direct tumor site injection (1 mg/kg/0.5 wk) in HepG2 xenograph mice is shown to increase the number of apoptotic cells and decrease the expression of β-catenin target genes (cyclin D1, c-Myc, survivin) in the tumor mass, resulting in an effective tumor growth retardation (by ~60% after a 4-wk treatment period) in vivo.
    产品目录编号 219331
    品牌系列 Calbiochem®
    同义词 1,6-Dimethylpyrimido[5,6-e][1,2,4]triazine-5,7-dione, Wnt Pathway Inhibitor X
    参考
    参考 Wei, W., et al. 2010. Int. J. Cancer 126, 2426.
    Lepourcelet, M., et al. 2004. Cancer Cell 5, 91.
    产品信息
    形式 Dark yellow solid
    Hill配方 C₇H₇N₅O₂
    化学配方 C₇H₇N₅O₂
    Molar Mass 193.2
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,219331,β-Catenin/Tcf Inhibitor II, PKF118-310 - Calbiochem

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