merck millipore,默克密理博,07-2174,Anti-Heat Shock Protein 90α Antibody

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merck millipore,默克密理博,07-2174,Anti-Heat Shock Protein 90α Antibody
产品名称：Anti-Heat Shock Protein 90α Antibody
产品型号：07-2174
Detect the Heat Shock Protein 90α protein using this Anti-Heat Shock Protein 90α validated for use in WB, IP, ICC & IHC.

merck millipore,默克密理博,07-2174,Anti-Heat Shock Protein 90α Antibody

产品介绍

merck millipore,默克密理博,07-2174,Anti-Heat Shock Protein 90α Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
Ca, H, M, R	IHC, WB, ICC	Rb	Purified	Polyclonal Antibody

描述
产品目录编号	07-2174
描述	Anti-Heat Shock Protein 90α Antibody
Alternate Names	heat shock 90kD protein 1, alpha-like 4 heat shock protein 90kDa alpha (cytosolic), class A member 1 Renal carcinoma antigen NY-REN-38 heat shock 90kD protein 1, alpha heat shock 90kD protein, alpha-like 4 heat shock 90kDa protein 1, alpha heat shock protein HSP 90-alpha Heat shock 86 kDa
背景信息	The Heat Shock Protein 90 family is known as a group of molecular chaperones involved in the regulation of maturation, degradation, and folding transport for a select, yet varied group of proteins primarily comprised of signaling molecules, but also including tyrosine kinases, G-protein subunits, transcription factors, and telomerase. Heat Shock Protein 90 has two isoforms that share a homology of 76%; Heat Shock Protein 90α (HSP90α) and Heat Shock Protein 90β (HSP90β). HSP90α contains a charged sequence linker, a C-terminal domain, and N-terminal domain and a middle domain. It is induced by oxidative stress and has been observed in exosomes where it is secreted into the extracellular environment following translocation via TGFα stimulus. Extracellular HSP90α functions to facilitate the migration of both dermal and epidermal cells through its interaction with cell surface receptors CD91 and LRP1. HSP90α interaction with TERT is a necessary component of TERT holoenzyme complex assembly and stabilization. It has also been shown to interact with a variety of other proteins such as FNIP1, HSF1, TOM34, AHSA1, SMYD3, and DNAJC7.

产品信息
格式	Purified
控制	HeLa cell lysate
演示	Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Detect the Heat Shock Protein 90α protein using this Anti-Heat Shock Protein 90α validated for use in WB, IP, ICC & IHC.
主要应用	Immunohistochemistry Western Blotting Immunocytochemistry
应用说明	Western Blot (Snap i.d.®) Analysis: 1 µg/mL from a previous lot detected Heat Shock Protein 90α on 10 µg of NIH/3T3 cell lysate. Immunohistochemistry Analysis: 1:100 dilution from a previous lot detected Heat Shock Protein 90α in human prostate adenocarcinoma tissue. Immunocytochemistry Analysis: 1:500 dilution from a previous ot detected Heat Shock Protein 90α in A431 cells. Immunoprecipitation Analysis: 10 µg from a previous lot immunoprecipitated Heat Shock Protein 90A from HeLa cell lysate.

生物信息
免疫原品种	KLH-conjugated linear peptide corresponding to the N-terminus of human Heat Shock Protein 90α.
表位	N-terminus
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	This antibody recognizes Heat Shock Protein 90α at the N-terminus.
品种反应性	CanineHumanMouseRat
Species Reactivity Note	Demonstrated to react with human, mouse, and rat. Predicted to react with canine based on 100% sequence homology.
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_001017963
Entrez基因汇总	HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 (MIM 140572), a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM].
基因符号	LAP2 HSP90AA1 HSPCAL4 HSPN HSP86 Hsp89 HSP90N HSPC1 HSP90A Hsp90 HSPCAL1 HSPCA
纯化方法	Protein A
UniProt编号	P07900
UniProt汇总	FUNCTION: Molecular chaperone. Has ATPase activity (By similarity). SIZE: 732 amino acids; 84660 Da SUBUNIT: Homodimer. Interacts with AHSA1, SMYD3 and TOM34. Interacts with FNIP1. SUBCELLULAR LOCATION: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. SIMILARITY: Belongs to the heat shock protein 90 family.

产品使用声明
质量保证	Evaluated by Western Blot in HeLa cell lysate. Western Blot Analysis: 0.0625 µg/mL of this antibody detected Heat Shock Protein 90α on 10 µg of HeLa cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,07-2174,Anti-Heat Shock Protein 90α Antibody

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