merck millipore,默克密理博,344850,Fumonisin B₁, Fusarium moniliforme - CAS 116355-83-0

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merck millipore,默克密理博,344850,Fumonisin B₁, Fusarium moniliforme - CAS 116355-83-0 - Calbiochem
产品名称：Fumonisin B₁, Fusarium moniliforme - CAS 116355-83-0 - Calbiochem
产品型号：344850
A cell-permeable mycotoxin that inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase; IC₅₀ = 100 nM).

merck millipore,默克密理博,344850,Fumonisin B₁, Fusarium moniliforme - CAS 116355-83-0 - Calbiochem

产品介绍

merck millipore,默克密理博,344850,Fumonisin B₁, Fusarium moniliforme - CAS 116355-83-0 - Calbiochem

重要规格表

经验配方	CAS号
C₃₄H₅₉NO₁₅	116355-83-0

描述
概述	A cell-permeable mycotoxin that inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase; IC₅₀ = 100 nM). Preferentially inhibits sphingomyelin biosynthesis in neuronal cells. Exhibits carcinogenic properties.
产品目录编号	344850
品牌系列	Calbiochem®
同义词	FB₁

参考
参考	Wu, W.I., et al. 1995. J. Biol. Chem. 270, 13171. Riley, R.T., et al. 1994. J. Nutr. 124, 594. Wolf, G. 1994. Nutr. Rev. 52, 246. Merrill, A.H. Jr., et al. 1993. Adv. Lipid Res. 26, 215. Merrill, Jr., A.H., et al. 1993. J. Biol. Chem. 268, 27299. Voss, K.A., et al. 1993. Nat. Toxins 1, 222. Wang, E., et al. 1991. J. Biol. Chem. 266, 14486. Harrison, L.R., et al. 1990. J. Vet. Diag. Invest. 2, 217.

参考

Wu, W.I., et al. 1995. J. Biol. Chem. 270, 13171.
Riley, R.T., et al. 1994. J. Nutr. 124, 594.
Wolf, G. 1994. Nutr. Rev. 52, 246.
Merrill, A.H. Jr., et al. 1993. Adv. Lipid Res. 26, 215.
Merrill, Jr., A.H., et al. 1993. J. Biol. Chem. 268, 27299.
Voss, K.A., et al. 1993. Nat. Toxins 1, 222.
Wang, E., et al. 1991. J. Biol. Chem. 266, 14486.
Harrison, L.R., et al. 1990. J. Vet. Diag. Invest. 2, 217.

产品信息
CAS号	116355-83-0
具有ATP竞争性	N
形式	White to beige powder
Hill配方	C₃₄H₅₉NO₁₅
化学配方	C₃₄H₅₉NO₁₅
Molar Mass	721.8
可逆	N
结构配方图像

生物信息
主靶	ceramide synthase
主靶IC₅₀	100 nM against sphingosine N-acyltransferase (ceramide synthase)
纯度	≥95% by TLC

理化信息
细胞可渗透	Y
溶解度	MeOH

GHS安全信息
RTECS	TZ8350000

安全信息
R相	R: 40 Limited evidence of a carcinogenic effect.
S相	S: 22-26-36/37/39 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection.

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Carcinogenic / Teratogenic
储存	+2°C to +8°C
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.