merck millipore,默克密理愽
  • merck millipore,默克密理博,553514,RAD51 Inhibitor II, RI-1 - Calbiochem

  • merck millipore,默克密理博,553514,RAD51 Inhibitor II, RI-1 - Calbiochem

    产品名称：RAD51 Inhibitor II, RI-1 - Calbiochem
    产品型号：553514
    The RAD51 Inhibitor, RI-1 controls the biological activity of RAD51. This small molecule/inhibitor is primarily used for Cell Structure applications.

    merck millipore,默克密理博,553514,RAD51 Inhibitor II, RI-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,553514,RAD51 Inhibitor II, RI-1 - Calbiochem

    重要规格表

    经验配方
    C₁₄H₁₁Cl₃N₂O₃
    描述
    概述 A cell-permeable 1H-Pyrrole-2,3-dione derivative that covalently binds to RAD51 at Cys319 and irreversibly destabilizes a protein-protein interface that is essential for filament formation and recombinase activity. Stimulates single strand annealing at a 5-30 µM concentration. Inhibits subnuclear RAD51 foci formation following DNA damage without affecting replication protein A. Also, effectively sensitizes cancer cells to mitomycin C (~25 µM) and generate synergistic cell kill in RAD51C mutant cells and with lesser effect on RAD51 complemented cells. Satisfies all four Lipinski rules for predicting drug likeness.
    产品目录编号 553514
    品牌系列 Calbiochem®
    同义词 3-chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione
    参考
    参考 Budke, B., et al. 2012. Nucleic Acids Res. 40, 7347.
    产品信息
    形式 Bright yellow solid
    Hill配方 C₁₄H₁₁Cl₃N₂O₃
    Molar Mass 361.61
    可逆 N
    结构配方图像
    生物信息
    主靶 RAD51
    主靶IC50 5-30 µ
    纯度 ≥99% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,553514,RAD51 Inhibitor II, RI-1 - Calbiochem

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