merck millipore,默克密理博,344282,Forskolin, Coleus forskohlii in DMSO

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merck millipore,默克密理博,344282,Forskolin, Coleus forskohlii in DMSO - Calbiochem
产品名称：Forskolin, Coleus forskohlii in DMSO - Calbiochem
产品型号：344282
The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii.

merck millipore,默克密理博,344282,Forskolin, Coleus forskohlii in DMSO - Calbiochem

产品介绍

merck millipore,默克密理博,344282,Forskolin, Coleus forskohlii in DMSO - Calbiochem

重要规格表

经验配方
C₂₂H₃₄O₇

描述
概述	The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC₅₀ = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na⁺ permeability that results in indirect augmentation of Ca²⁺ release. Inhibits MAP kinase in rat renal mesangial cells (IC₅₀ = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes. The solid form of this compound (Cat. No. 344270) is also available.
产品目录编号	344282
品牌系列	Calbiochem®

参考
参考	D'Orazio, J.A., et al. 2006. Nature 443, 340. Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180. Galli, C., et al. 1995. J. Neurosci. 15, 1172. Li, X., et al. 1995. Am. J. Physiol. 269, C986. Lomo, J., et al. 1995. J. Immunol. 154, 1634. Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168. Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442. Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217. Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1. Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385. Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.

参考

D'Orazio, J.A., et al. 2006. Nature 443, 340.
Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
Galli, C., et al. 1995. J. Neurosci. 15, 1172.
Li, X., et al. 1995. Am. J. Physiol. 269, C986.
Lomo, J., et al. 1995. J. Immunol. 154, 1634.
Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168.
Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442.
Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217.
Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1.
Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385.
Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.

产品信息
形式	Liquid
配方	A 50 mM (5 mg/244 µl) solution of Forskolin, Coleus forskohlii (Cat. No. 344270) in DMSO.
Hill配方	C₂₂H₃₄O₇
化学配方	C₂₂H₃₄O₇
Molar Mass	410.5
吸湿	Hygroscopic
结构配方图像

生物信息
纯度	≥97% by HPLC

安全信息
R相	R: 36/38 Irritating to eyes and skin.
S相	S: 26-36-45 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Dry Ice Only
毒性	Irritant
储存	-20°C
避光	Protect from light
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following initial thaw, aliquot and freeze (-20°C).