merck millipore,默克密理愽
  • merck millipore,默克密理博,MABT199,Anti-Integrin Beta1 Antibody, clone 8E3

  • merck millipore,默克密理博,MABT199,Anti-Integrin Beta1 Antibody, clone 8E3

    产品名称：Anti-Integrin Beta1 Antibody, clone 8E3
    产品型号：MABT199
    This Anti-Integrin beta1 Antibody is validated for use in WB, IP & activity assays for the detection of Integrin beta1.

    merck millipore,默克密理博,MABT199,Anti-Integrin Beta1 Antibody, clone 8E3

  • 产品介绍
  • merck millipore,默克密理博,MABT199,Anti-Integrin Beta1 Antibody, clone 8E3

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HACT, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABT199
    描述 Anti-Integrin Beta1 Antibody, clone 8E3
    Alternate Names
    • CD29
    • Integrin beta-1
    • Fibronectin receptor subunit beta
    • VLA-4 subunit beta
    背景信息 Integrin beta1 is a transmembrane glycoprotein that forms noncovalent complexes with various alpha integrin subunits to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells. Interactions between integrins and extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. Phosphorylation of threonines 788 and 789 on integrin beta1 receptor may play a key role in cell-cycle dependent regulation.
    产品信息
    格式 Purified
    控制
    • HT-1080 cell lysate
    演示 Purified mouse monoclonal IgG1κ in buffer containing PBS without preservatives.
    应用
    应用 This Anti-Integrin beta1 Antibody is validated for use in WB, IP & activity assays for the detection of Integrin beta1.
    主要应用
    • Activity Assay
    • Western Blotting
    应用说明 Western Blot Analysis: A 1:100,000 dilution from a representative lot detected Integrin protein in WB under non-reducing conditions.

    Activity Assay Analysis: A representative lot from an independent laboratory stimulated cellular adhesion and increased ligand binding activity of Integrin Beta1 (Mould, A. P., et al. (2004). J Biol Chem. 280(56):4238-4226.).

    Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated Integrin Beta1 in IP (Tiwari, S., et al. (2011). J Cell Sci. 124(10):1672-1680.).
    生物信息
    免疫原品种 Purified Integrin Beta1 from HT-1080 cells.
    表位 N-terminus of the PSI domain
    克隆 8E3
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes the N-terminus of the PSI domain of Integrin Beta1. Under native conditions, clone 8E3 is shown to recognize the unbent, monomeric ER form of Integrin Beta1 at the PSI domain; however, the epitope only becomes exposed in the Golgi form after denaturation. This observation suggests that the epitopes are present in monomeric beta 1-integrins, but become lost following assembly with alpha-integrin subunits (Tiwari, S., et al. (2011). J Cell Sci. 124(10):1672-1680.; Mould, A. P., et al. (2004). J Biol Chem. 280(56):4238-4226.)
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_002202
    基因符号
    • MSK12
    • ITGB
    • FNRB
    • MDF2
    纯化方法 Protein G purified
    UniProt编号
    • P05556
    产品使用声明
    质量保证 Evaluated by Western Blot in HT-1080 cell lysate.

    Western Blot Analysis: A 1:2,000 dilution of this antibody detected Integrin Beta1 in 10 µg of HT-1080 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MABT199,Anti-Integrin Beta1 Antibody, clone 8E3

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