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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M ICC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-415 品牌系列 Upstate
商名 - Upstate
描述 Anti-Sam 68 Antibody 产品信息 格式 Serum 演示 0.1M Trisglycine,pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Anti-Sam 68 Antibody is a high quality Rabbit Polyclonal Antibody for the detection of Sam 68 & has been validated in IP, WB, ICC. 主要应用 - Immunocytochemistry
- Western Blotting
生物信息 免疫原品种 Peptide corresponding to residues 331-348 of human Sam 68 宿主 Rabbit 特异性 Sam 68 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_006559
基因符号 - p62
- KHDRBS1
- Sam68
- FLJ34027
- SAM68
- p68
纯化方法 Antiserum UniProt编号 - Q07666
UniProt汇总 FUNCTION: SwissProt: Q07666 # Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase.
SIZE: 443 amino acids; 48227 Da
SUBUNIT: Self-associates to form homo-oligomers when bound to RNA, oligomerization appears to be limited when binding to proteins. Interacts with CBL, KHDRBS3, LCK, GRB2, JAK3, PIK3R1, PLCG1, PTPN6, RASA1, and STAT3. Interacts with PRMT1. Binds the WW domains of WBP4/FBP21, FNBP4/FBP30 and the SH3 domain of FYN through the Arg/Gly-rich-flanked Pro-rich regions (By similarity).
SUBCELLULAR LOCATION: Nucleus. Membrane.
TISSUE SPECIFICITY: Ubiquitously expressed in all tissue examined. Isoform 1 is expressed at lower levels in brain, skeletal muscle, and liver whereas isoform 3 is intensified in skeletal muscle and in liver.
DEVELOPMENTAL STAGE: Isoform 3 is only expressed in growth- arrested cells.
DOMAIN: SwissProt: Q07666 The KH domain is required for binding to RNA (By similarity). & The Pro-rich domains are flanked by Arg/Gly-rich motifs which can be asymmetric dimethylated on arginine residues to give the DMA/Gly-rich regions. Selective methlylation on these motifs can modulate protein-protein interactions (By similarity).
PTM: Tyrosine phosphorylated by several non-receptor tyrosine kinases, for example LCK, FYN and JAK3. Negatively correlates with ability to bind RNA but required for many interactions with proteins. & Acetylated. Positively correlates with ability to bind RNA. & Arginine methylation is required for nuclear localization. Also can affect interaction with other proteins. Inhibits interaction with Src-like SH3 domains, but not interaction with WW domains of WBP4/FBP21 AND FNBP4/FBP30. & Arg-291, Arg-331 and Arg-346 are found to be also dimethylated, probably to asymmetric dimethylarginine.
SIMILARITY: Belongs to the KHDRBS family. & Contains 1 KH domain.产品使用声明 质量保证 routinely evaluated by immunoblot in RIPA lysates from HeLa cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µL
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