merck millipore,默克密理博,344270,Forskolin, Coleus forskohlii - CAS 66575-29-9

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merck millipore,默克密理博,344270,Forskolin, Coleus forskohlii - CAS 66575-29-9 - Calbiochem
产品名称：Forskolin, Coleus forskohlii - CAS 66575-29-9 - Calbiochem
产品型号：344270
The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii.

merck millipore,默克密理博,344270,Forskolin, Coleus forskohlii - CAS 66575-29-9 - Calbiochem

产品介绍

merck millipore,默克密理博,344270,Forskolin, Coleus forskohlii - CAS 66575-29-9 - Calbiochem

重要规格表

经验配方	CAS号
C₂₂H₃₄O₇	66575-29-9

描述
概述	The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC₅₀ = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na⁺ permeability that results in indirect augmentation of Ca²⁺ release. Inhibits MAP kinase in rat renal mesangial cells (IC₅₀ = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes.
产品目录编号	344270
品牌系列	Calbiochem®
同义词	7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxy-labd-14-en-11-one, Colforsin

参考
参考	D'Orazio, J.A., et al. 2006. Nature 443, 340. Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180. Galli, C., et al. 1995. J. Neurosci. 15, 1172. Li, X., et al. 1995. Am. J. Physiol. 269, C986. Lomo, J., et al. 1995. J. Immunol. 154, 1634. Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168. Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442. Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217. Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1. Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385. Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.

参考

D'Orazio, J.A., et al. 2006. Nature 443, 340.
Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
Galli, C., et al. 1995. J. Neurosci. 15, 1172.
Li, X., et al. 1995. Am. J. Physiol. 269, C986.
Lomo, J., et al. 1995. J. Immunol. 154, 1634.
Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168.
Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442.
Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217.
Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1.
Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385.
Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.

产品信息
CAS号	66575-29-9
具有ATP竞争性	N
形式	White to off-white crystalline solid
Hill配方	C₂₂H₃₄O₇
化学配方	C₂₂H₃₄O₇
Molar Mass	410.5
可逆	N
结构配方图像

生物信息
主靶	Adenylate cyclase
主靶IC₅₀	25 µM inhibiting MAP kinase in rat renal mesangial cells; EC50 = 4 µM for activation of adenylate cyclase
纯度	≥99% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO

GHS安全信息
RTECS	QL6150000

安全信息
R相	R: 21 Harmful in contact with skin.
S相	S: 36 Wear suitable protective clothing.

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Harmful
储存	+15°C to +30°C
无需冷冻	No
特殊指南	Following reconstitution, store in the refrigerator (4°C). DMSO stock solutions are stable for up to 4 months at 4°C.