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merck millipore,默克密理博,262017,APE1 Inhibitor III - Calbiochem
产品名称：APE1 Inhibitor III - Calbiochem
产品型号：262017
The APE1 Inhibitor III controls the biological activity of APE1. This small molecule/inhibitor is primarily used for Cell Structure applications.
merck millipore,默克密理博,262017,APE1 Inhibitor III - Calbiochem
- 产品介绍
重要规格表
经验配方 C₁₉H₂₁N₃OS₂ 描述 概述 A cell-permeable benzothiazolyltetrahydrothienopyridine compound that acts as a potent, competitive, and active site targeting inhibitor of APE1 (IC50 = 2.0 µM in a fluorescence based HTS assay; and 12 .0 µM in a radiotracer incision assay). Shown to block APE1 activity in HEK293T and HeLa cells extract (IC50 = 600 nM) and increase genomic AP site accumulation. Potentiates the cytotoxicity of DNA-damaging alkylating agents in HeLa cells by ~3-fold. Exhibits favorable pharmacokinetic properties and desirable ADME attributes. Due to its lipophilic nature, it crosses the blood-brain barrier rather easily and shows desirable stability (t1/2 = 80 min). 产品目录编号 262017 品牌系列 Calbiochem®
同义词 N-(3-(1,3-Benzo[d]thiazol-2-yl)-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide, Apurinic Endonuclease 1 Inhibitor III, Apurinic/Apyrimidinic Endonuclease 1 Inhibitor III 参考 参考 Rai, G., et al. 2012. J. Med. Chem. 55, 3101. 产品信息 形式 Brown solid Hill配方 C₁₉H₂₁N₃OS₂ Molar Mass 371.5 可逆 Y 结构配方图像 生物信息 主靶 APE1 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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